Diadenozin heksafosfatna hidrolaza (formira AMP)

Diadenozin heksafosfatna hidrolaza (formira AMP)
Identifikatori
EC broj	3.6.1.60
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

Diadenozin heksafosfatna hidrolaza (formira AMP) (EC 3.6.1.60, hAps1, NUDT11 (gen), hAps2, NUDT10 (gen)) je enzim sa sistematskim imenom P1,P6-bis(5'-adenozil)heksafosfat nukleotidohidrolaza (formira AMP).^[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) P1,P6-bis(5'-adenozil)heksafosfat + H₂O ${\displaystyle \rightleftharpoons }$ adenozin 5'-pentafosfat + AMP

(2) P1,P5-bis(5'-adenozil)pentafosfat + H₂O ${\displaystyle \rightleftharpoons }$ adenozin 5'-tetrafosfat + AMP

Dvovalentni kation je esencijalan za aktivnost.

Reference

1. Leslie, N.R., McLennan, A.G. and Safrany, S.T. (2002). „Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases”. BMC Biochem. 3: #20—20. PMID 12121577. CS1 одржавање: Вишеструка имена: списак аутора (веза)
2. Safrany, S.T., Ingram, S.W., Cartwright, J.L., Falck, J.R., McLennan, A.G., Barnes, L.D. and Shears, S.B. (1999). „The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein”. J. Biol. Chem. 274: 21735—21740. PMID 10419486. CS1 одржавање: Вишеструка имена: списак аутора (веза)

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 
• William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605. 

Spoljašnje veze

• Diadenosine+hexaphosphate+hydrolase+(AMP-forming) на US National Library of Medicine Medical Subject Headings (MeSH)