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Desosaminil transferaza EryCIII
Desosaminil transferaza EryCIII
Identifikatori
EC broj	2.4.1.278
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
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NCBI	proteini

Desosaminil transferaza EryCIII (EC 2.4.1.278, EryCIII) je enzim sa sistematskim imenom dTDP-3-dimetilamino-4,6-didezoksi-alfa-D-glukopiranoza:3-alfa-mikarosileritronolid B 3-dimetilamino-4,6-didezoksi-alfa-D-glukoziltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

dTDP-3-dimetilamino-4,6-didezoksi-alfa-D-glukopiranoza + 3-alfa-mikarosileritronolide B

\rightleftharpoons

dTDP + eritromicin D

Ovaj enzim učestvuje u biosintezi eritromicina.

Reference

^ Yuan, Y., Chung, H.S., Leimkuhler, C., Walsh, C.T., Kahne, D. and Walker, S. (2005). „In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides”. J. Am. Chem. Soc. 127: 14128—14129. PMID 16218575.
^ Lee, H.Y., Chung, H.S., Hang, C., Khosla, C., Walsh, C.T., Kahne, D. and Walker, S. (2004). „Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway”. J. Am. Chem. Soc. 126: 9924—9925. PMID 15303858.
^ Moncrieffe, M.C., Fernandez, M.J., Spiteller, D., Matsumura, H., Gay, N.J., Luisi, B.F. and Leadlay, P.F. (2012). „Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII”. J. Mol. Biol. 415: 92—101. PMID 22056329.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Desosaminyl+transferase+EryCIII на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Yuan, Y., Chung, H.S., Leimkuhler, C., Walsh, C.T., Kahne, D. and Walker, S. (2005). „In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides”. J. Am. Chem. Soc. 127: 14128—14129. PMID 16218575.

[2] Lee, H.Y., Chung, H.S., Hang, C., Khosla, C., Walsh, C.T., Kahne, D. and Walker, S. (2004). „Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway”. J. Am. Chem. Soc. 126: 9924—9925. PMID 15303858.

[3] Moncrieffe, M.C., Fernandez, M.J., Spiteller, D., Matsumura, H., Gay, N.J., Luisi, B.F. and Leadlay, P.F. (2012). „Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII”. J. Mol. Biol. 415: 92—101. PMID 22056329.

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