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Hemokin (C-C motiv) ligand 11
Hemokin (C-C motiv) ligand 11
	PDB prikaz baziran na 1eot.
Dostupne strukture
	1eot, 2eot
Identifikatori
Simboli	CCL11; MGC22554; SCYA11
Vanjski ID	OMIM: 601156 MGI: 103576 HomoloGene: 7929 GeneCards: CCL11 Gene
Ontologija gena
Molekularna funkcija	• hemokinska aktivnost;
Celularna komponenta	• ekstracelularni region; • ekstracelularni prostor;
Biološki proces	• proteinska aminokiselinska fosforilacija; • ćelijska homeostaza kalcijum jona; • hemotaksa; • inflamatorni odgovor; • imunski odgovor; • ćelijski odbrambeni respons; • ćelijska adhezija; • transdukcija signala; • interćelijska signalizacija; • respons na radijaciju; • respons na viruse;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	6356
Ensembl	ENSG00000172156
UniProt	P51671
RefSeq (mRNA)	NM_002986
RefSeq (protein)	NP_002977
Lokacija (UCSC)	Chr 17:; 29.64 - 29.64 Mb
PubMed pretraga	[1]

CCL11, hemokin (C-C motiv) ligand 11, je mali citokin iz CC hemokin familije. On je takođe poznat kao eotaksin-1. CCL11 selektivno regrutuje eozinofile putem indukovanja njihove hemotakse, i zato je impliciran u alergijske response.^[1]^[2]^[3]

Efekti CCL11 su posredovani njegovim vezivanjem za G-protein spregnuti hemokin receptor. Hemokin receptori CCL11 liganda su CCR2^[4], CCR3^[5] i CCR5.^[4] Međutim, bilo je ustanovljeno da eotaksin-1 (CCL11) ima visok stepen selektivnosti za CCR3 receptor, tako da je neaktivan na neutrofilima i monocitima, koji ne izražavaju CCR3.^[6] Gen ljudskog CCL11 (SCYA11) je kodiran sa tri eksona i lociran je na hromozomu 17.^[5]^[7]

Reference

^ Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR (1996). „Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils”. J. Clin. Invest. 97 (3): 604—12. PMC 507095 . PMID 8609214. doi:10.1172/JCI118456. ^{[мртва веза]}
^ Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (1996). „Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia”. Nat. Med. 2 (4): 449—56. PMID 8597956. doi:10.1038/nm0496-449.
^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
^ ^а ^б Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M (2001). „Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5”. Blood. 97 (7): 1920—4. PMID 11264152. doi:10.1182/blood.V97.7.1920.
^ ^а ^б Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O (1996). „Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3”. J. Biol. Chem. 271 (13): 7725—30. PMID 8631813. doi:10.1074/jbc.271.13.7725.
^ Baggiolini M, Dewald B, Moser B (1997). „Human chemokines: an update”. Annu. Rev. Immunol. 15: 675—705. PMID 9143704. doi:10.1146/annurev.immunol.15.1.675.
^ Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J (1997). „Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene”. Biochem. Biophys. Res. Commun. 237 (3): 537—42. PMID 9299399. doi:10.1006/bbrc.1997.7169.

Literatura

Garcia-Zepeda EA; Rothenberg ME; Ownbey RT; et al. (1996). „Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia.”. Nat. Med. 2 (4): 449—56. PMID 8597956. doi:10.1038/nm0496-449.
Ponath PD; Qin S; Ringler DJ; et al. (1996). „Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.”. J. Clin. Invest. 97 (3): 604—12. PMC 507095 . PMID 8609214. doi:10.1172/JCI118456.
Kitaura M; Nakajima T; Imai T; et al. (1996). „Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3.”. J. Biol. Chem. 271 (13): 7725—30. PMID 8631813. doi:10.1074/jbc.271.13.7725.
Daugherty BL; Siciliano SJ; DeMartino JA; et al. (1996). „Cloning, expression, and characterization of the human eosinophil eotaxin receptor.”. J. Exp. Med. 183 (5): 2349—54. PMC 2192548 . PMID 8642344. doi:10.1084/jem.183.5.2349.
Choe H; Farzan M; Sun Y; et al. (1996). „The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.”. Cell. 85 (7): 1135—48. PMID 8674119. doi:10.1016/S0092-8674(00)81313-6.
Ponath PD; Qin S; Post TW; et al. (1996). „Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils.”. J. Exp. Med. 183 (6): 2437—48. PMC 2192612 . PMID 8676064. doi:10.1084/jem.183.6.2437.
Bartels J; Schlüter C; Richter E; et al. (1996). „Human dermal fibroblasts express eotaxin: molecular cloning, mRNA expression, and identification of eotaxin sequence variants.”. Biochem. Biophys. Res. Commun. 225 (3): 1045—51. PMID 8780731. doi:10.1006/bbrc.1996.1292.
Garcia-Zepeda EA; Rothenberg ME; Weremowicz S; et al. (1997). „Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine.”. Genomics. 41 (3): 471—6. PMID 9169149. doi:10.1006/geno.1997.4656.
Hein H; Schlüter C; Kulke R; et al. (1997). „Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene.”. Biochem. Biophys. Res. Commun. 237 (3): 537—42. PMID 9299399. doi:10.1006/bbrc.1997.7169.
Nibbs RJ; Wylie SM; Yang J; et al. (1998). „Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6.”. J. Biol. Chem. 272 (51): 32078—83. PMID 9405404. doi:10.1074/jbc.272.51.32078.
Rubbert A; Combadiere C; Ostrowski M; et al. (1998). „Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry.”. J. Immunol. 160 (8): 3933—41. PMID 9558100.
Noso N; Bartels J; Mallet AI; et al. (1998). „Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts.”. Eur. J. Biochem. 253 (1): 114—22. PMID 9578468. doi:10.1046/j.1432-1327.1998.2530114.x.
Crump MP; Rajarathnam K; Kim KS; et al. (1998). „Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation.”. J. Biol. Chem. 273 (35): 22471—9. PMID 9712872. doi:10.1074/jbc.273.35.22471.
Sabroe I; Hartnell A; Jopling LA; et al. (1999). „Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways.”. J. Immunol. 162 (5): 2946—55. PMID 10072545.
Jinquan T; Quan S; Feili G; et al. (1999). „Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4.”. J. Immunol. 162 (7): 4285—92. PMID 10201960.
Klein RS; Williams KC; Alvarez-Hernandez X; et al. (1999). „Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS.”. J. Immunol. 163 (3): 1636—46. PMID 10415069.
Blanpain C; Migeotte I; Lee B; et al. (1999). „CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist.”. Blood. 94 (6): 1899—905. PMID 10477718.
Zhang J, Lathbury LJ, Salamonsen LA (2000). „Expression of the chemokine eotaxin and its receptor, CCR3, in human endometrium.”. Biol. Reprod. 62 (2): 404—11. PMID 10642580. doi:10.1095/biolreprod62.2.404.
Kampen GT; Stafford S; Adachi T; et al. (2000). „Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases.”. Blood. 95 (6): 1911—7. PMID 10706854.
Huber MA, Kraut N, Addicks T, Peter RU (2000). „Cell-type-dependent induction of eotaxin and CCR3 by ionizing radiation.”. Biochem. Biophys. Res. Commun. 269 (2): 546—52. PMID 10708591. doi:10.1006/bbrc.2000.2287.

Spoljašnje veze

CCL11 GeneCard

[pmid8609214-1] Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR (1996). „Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils”. J. Clin. Invest. 97 (3): 604—12. PMC 507095 . PMID 8609214. doi:10.1172/JCI118456. ^{[мртва веза]}

[pmid8597956-2] Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (1996). „Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia”. Nat. Med. 2 (4): 449—56. PMID 8597956. doi:10.1038/nm0496-449.

[3] Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

[pmid11264152-4] а ^б Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M (2001). „Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5”. Blood. 97 (7): 1920—4. PMID 11264152. doi:10.1182/blood.V97.7.1920.

[pmid8631813-5] а ^б Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O (1996). „Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3”. J. Biol. Chem. 271 (13): 7725—30. PMID 8631813. doi:10.1074/jbc.271.13.7725.

[pmid9143704-6] Baggiolini M, Dewald B, Moser B (1997). „Human chemokines: an update”. Annu. Rev. Immunol. 15: 675—705. PMID 9143704. doi:10.1146/annurev.immunol.15.1.675.

[pmid9299399-7] Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J (1997). „Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene”. Biochem. Biophys. Res. Commun. 237 (3): 537—42. PMID 9299399. doi:10.1006/bbrc.1997.7169.

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