23S rRNK (guanin1835-N2)-metiltransferaza

23S rRNK (guanin^1835-N^2)-metiltransferaza
Identifikatori
EC broj	2.1.1.174
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

23S rRNK (guanin¹⁸³⁵-N²)-metiltransferaza (EC 2.1.1.174, ygjO (gen), rlmG (gen), metiltransferaza G ribozomalne RNK velike podjedinice) je enzim sa sistematskim imenom S-adenozil-L-metionin:23S rRNK (guanin¹⁸³⁵-N²)-metiltransferaza.^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + guanin¹⁸³⁵ u 23S rRNK ${\displaystyle \rightleftharpoons }$ S-adenozil-L-homocistein + N²-metilguanin¹⁸³⁵ u 23S rRNK

Ovaj enzim metiliše 23S rRNK in vitro. Formirane 50S podjedinice nisu supstrat. Enzim specifično metiliše guanin¹⁸³⁵ u N² poziciji unutar 23S rRNK.

Reference

1. Sergiev, P.V., Lesnyak, D.V., Bogdanov, A.A. and Dontsova, O.A. (2006). „Identification of Escherichia coli m²G methyltransferases: II. The ygjO gene encodes a methyltransferase specific for G1835 of the 23 S rRNA”. J. Mol. Biol. 364: 26—31. PMID 17010380. CS1 одржавање: Вишеструка имена: списак аутора (веза)

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 
• William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605. 

Spoljašnje veze

• 23S+rRNA+(guanine1835-N2)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)