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RITA (también denominada NSC 652287) es una molécula de bajo peso molecular que actúa como inhibidor en la formación del complejo p53-MDM2. Sus siglas significan Reactivation of p53 and Induction of Tumor cell Apoptosis (RITA). Al disminuir esta interacción la p53 queda intacta, la cual induce la apoptosis de la célula. Además esta molécula está implicada en la acumulación de la p53 en células tumorales, función que sirve hoy en día en el tratamiento contra el cáncer, aunque aú...
Swedish film director and screenwriter Måns MårlindMårlind in 2012BornMåns Magnus Mårlind (1969-07-29) 29 July 1969 (age 54)Vallentuna, Stockholm County, SwedenOccupationsDirectorscreenwriterYears active1997–presentPartnerTuppence MiddletonChildren1[1] Måns Magnus Mårlind (born 29 July 1969) is a Swedish director and screenwriter. After making his feature film debut in 2005, he co-directed the big-budget horror films Shelter (2010) and Underworld: Awakening (2012) a...
Джоел Ембіід Joel Embiid Ембіід з Філадельфією Севенті Сіксерс в 2019 році Філадельфія Севенті Сіксерс — № 21 Центровий / Важкий форвард Особисті дані Прізвиська: Процес Зріст: 213 cм Вага: 127 кг Громадянство: Камерун Народився: 16 березня 1994 (29 років)(19940316) Яунде, Мфунд...
Union Army general For other people with the same name, see Charles Phelps. Charles Edward PhelpsJudge of the Circuit Court of BaltimoreIn office1882–1908Member of theU.S. House of Representativesfrom Maryland's 3rd congressional districtIn officeMarch 4, 1865 – March 3, 1869Preceded byHenry Winter DavisSucceeded byThomas SwannMember of theBaltimore City CouncilIn office1860–1861 Personal detailsBorn(1833-05-01)May 1, 1833Guilford, Vermont, USDiedDecember 27, 1908(1908-12-27) (...
WannabeSingel oleh Spice Girlsdari album SpiceSisi-BBumper to BumperDirilis26 Juni 1996 (1996-06-26)Format12kasetCDDirekamDesember 1995StudioStrongroom, LondonGenreDance-popDurasi2:52LabelVirginPenciptaSpice GirlsMatt RoweRichard StannardProduserMatt RoweRichard StannardKronologi singel Spice Girls Wannabe (1996) Say You'll Be There (1996) Video musikWannabe di YouTube Wannabe adalah singel debut oleh grup musik wanita Inggris Spice Girls. Ditulis dan disusun oleh anggota grup bekerja sa...
Las leyes de Cassini son una descripción compacta del movimiento de la Luna. Las mismas fueron formuladas en 1693 por Giovanni Domenico Cassini, un destacado científico de su época.[1] Se han realizado ciertos refinamientos de las leyes para incluir libraciones físicas,[1] y han sido generalizadas para aplicarlas a otros satélites y planetas.[2][3] Leyes de Cassini Inclinación de la órbita y rotación. La Luna posee una resonancia órbita-spin 1:1. Esto sign...
Lithuanian athletics competitor Mykolas AleknaAlekna in Munich 2022Personal informationNationalityLithuanianBorn (2002-09-28) 28 September 2002 (age 21)Height1.94 m (6 ft 4+1⁄2 in)SportCountryLithuaniaSportAthleticsEventDiscus throwCollege teamCalifornia Golden BearsAchievements and titlesPersonal best71.00 m (232 ft 11+1⁄4 in) (Berkeley 2023) Medal record Men's athletics Representing Lithuania World Championships 2022 Eugene Discus throw 2...
Pure TranceEnglish-language cover as published by Last Gasp (2005)ピュア・トランス(Pyua Toransu)GenreScience fiction MangaWritten byJunko MizunoPublished byEast PressEnglish publisherNA: Last GaspMagazineBooklets with CDs released by Avex TraxDemographicShōjoOriginal run1996 – 1998Volumes1 Pure Trance (Japanese: ピュア・トランス, Hepburn: Pyua Toransu) is a shōjo (targeted towards girls) science-fiction manga by Junko Mizuno. Her debut manga, it appeared as a ser...
هذه المقالة يتيمة إذ تصل إليها مقالات أخرى قليلة جدًا. فضلًا، ساعد بإضافة وصلة إليها في مقالات متعلقة بها. (أبريل 2023) زلزال باكو 2000 Tbilisi Shamakhi زلزال باكو 2000 (أذربيجان) معلومات التاريخ 25 نوفمبر 2000 العمق 35 كـم (22 ميل) [1] مكان الزلزال 40°15′N 49°54′E / 40.25°N 49.9°E...
Cargo steamship that became a Japanese hell ship Jun'yō Maru in 1933 History Name 1913: Ardgorm 1917: Hartland Point 1918: Hartmore 1921: Sureway 1927: Junyo Maru 1938: Zyunyo Maru Namesake1917: Hartland Point Owner 1913: SS Ardgorm Co 1917: Norfolk & N American SS Co 1918: Johnston Line 1921: Anglo-Oriental Nav Co 1927: Sanyo ShaGoshi K 1928: Kabafuto Kisen KK 1938: Baba Shoji KK Operator 1913: Lang & Fulton 1917: Furness, Withy & Co 1921: Yule, Catto & Co Port of registry 1...
American ultralight trike aircraft Maverick North Wing Maverick Legend Role Ultralight trikeType of aircraft National origin United States Manufacturer North Wing Design Status In production Number built 10 (February 2000) The North Wing Maverick is an American single-seat ultralight trike designed and produced by North Wing Design of East Wenatchee, Washington. The aircraft is supplied as a kit for amateur construction.[1][2][3][4] Design and development The a...
Notably expensive iOS application I Am RichI Am Rich, as it appeared in the United States' version of the App StoreDeveloper(s)Armin HeinrichInitial releaseAugust 5, 2008;15 years ago (2008-08-05)Operating systemiPhone OSAvailable inEnglish I Am Rich is a 2008 mobile app for iPhones which had minimal function and was priced at US$999.99 (equivalent to $1,359 in 2022). The app was pulled from the App Store less than 24 hours after its launch. Receiving poor reviews from criti...
46°46′09″N 23°35′12″E / 46.7692686°N 23.5865425°E / 46.7692686; 23.5865425 The Ethnographic Museum of Transylvania (Romanian: Muzeul Etnografic al Transilvaniei; Hungarian: Erdélyi néprajzi múzeum) is situated in Cluj-Napoca, Romania. With a history of almost 100 years, the Ethnographic Museum of Transylvania is one of the first and greatest of its kind in Romania. It has two exhibition sections, one of which is to be found in downtown Reduta Palace (21,...
Dainichi Kofun大日古墳Dainichi KofunDainichi KofunShow map of Yamaguchi PrefectureDainichi Kofun (Japan)Show map of JapanLocationHōfu, Yamaguchi, JapanRegionSan'yō regionCoordinates34°4′20.53″N 131°32′51.5″E / 34.0723694°N 131.547639°E / 34.0723694; 131.547639TypeKofunHistoryFoundedc.7th centuryPeriodsKofun periodSite notesPublic accessYes (no facilities)National Historic Site of Japan The Dainichi Kofun (大日古墳) is a Kofun period burial mo...
神学者聖ヨハネ修道院と黙示録の洞窟を含むパトモス島の歴史地区(ホーラ)(ギリシャ) 聖ヨハネ修道院から見下ろした景観英名 The Historic Centre (Chorá) with the Monastery of Saint-John the Theologian and the Cave of the Apocalypse on the Island of Pátmos仏名 Centre historique (Chorá) avec le monastère de Saint Jean « le théologien » et la grotte de l'Apocalypse sur l'île de Patmos登録区分 文化遺産登録基準 (...
Rockstar Interactive India LLP Тип Дочерняя компания Основание август 2016; 7 лет назад (2016-08) Прежние названия Technicolor India Расположение Индия: Бангалор, Карнатака Ключевые фигуры Даниэль Смит (глава студии) Отрасль индустрия компьютерных игр Продукция Разработка компьют...
У Вікіпедії є статті про інші значення цього терміна: Владимирський. Владимирський Лев Анатолійович Народження 27 вересня 1903(1903-09-27)Атирау, Уральська область, Російська імперіяСмерть 7 вересня 1973(1973-09-07) (69 років)Москва, СРСРПоховання Новодівичий цвинтарКраїна СРСРОсві...
Species of bird Pacific black duck Conservation status Least Concern (IUCN 3.1)[1] Scientific classification Domain: Eukaryota Kingdom: Animalia Phylum: Chordata Class: Aves Order: Anseriformes Family: Anatidae Genus: Anas Species: A. superciliosa Binomial name Anas superciliosaGmelin, 1789 Subspecies See text Natural range of the Pacific black duck The Pacific black duck (Anas superciliosa) is a dabbling duck found in much of Indonesia, New Guinea, Australia, New Zealand, a...
Coordenadas: 20°12'23.4S 43°28'01.6W Rompimento da barragem em Mariana Rompimento de barragem em Mariana Data 5 de novembro de 2015 Danos Lista destruição de Bento Rodrigues e Paracatu de Baixo aumento da turbidez das águas do rio Doce, com impactos no abastecimento de água em cidades de Minas Gerais e Espírito Santo danos culturais a monumentos históricos do período colonial danos à fauna e à flora na área da bacia hidrográfica, incluindo possível extinção de espécies endêm...
Russian freestyle skier Semen DenshchikovPersonal informationNationalityRussianBorn (1993-04-10) 10 April 1993 (age 30)Height1.87 m (6 ft 2 in)SportSportFreestyle skiing Semen Denshchikov (born 10 April 1993) is a Russian freestyle skier. He competed in the 2018 Winter Olympics.[1] References ^ Athlete Profile: Semen DENSHCHIKOV - Pyeongchang 2018 Olympic Winter Games. www.pyeongchang2018.com. Archived from the original on 2018-02-27. Retrieved 2018-02-27. This bio...