DNA damage theory of ageing

The DNA damage theory of ageing is that ageing happens because damage happens in the individual's DNA. The damage accumulates (builds up) even though there are cell mechanisms that repair most of the damage.

Although both mitochondrial and the cell nucleus may have DNA damage, nuclear DNA is the main subject of this analysis.^[1][2][3]

References

1. Best, BP (2009). "Nuclear DNA damage as a direct cause of aging" (PDF). Rejuvenation Research. 12 (3): 199–208. doi:10.1089/rej.2009.0847. PMID 19594328.
2. Freitas AA, de Magalhães JP (2011). "A review and appraisal of the DNA damage theory of ageing". Mutation Research. 728 (1–2): 12–22. doi:10.1016/j.mrrev.2011.05.001. PMID 21600302.
3. Burhans WC1, Weinberger M (2007). "DNA replication stress, genome instability and aging". Nucleic Acids Research. 35 (22): 7545–7556. doi:10.1093/nar/gkm1059. PMC 2190710. PMID 18055498.