Principi has worked on national policy issues and has held several executive-level positions in federal government throughout his career. He chaired the Federal Quality Institute in 1991, and was chairman of the Commission on Servicemembers and Veterans Transition Assistance established by Congress in 1996.[2]
Principi served as Deputy Secretary of Veterans Affairs, VA's second-highest executive position, from March 17, 1989, to September 26, 1992, when he was picked Acting Secretary of Veterans Affairs by President George H. W. Bush. He served in that position until January 1993. After that, he served as Republican chief counsel and staff director of the United States Senate Committee on Armed Services.
From 1984 to 1988, he served as Republican chief counsel and staff director of the Senate Committee on Veterans' Affairs. He was the Veterans Administration's assistant deputy administrator for congressional and public affairs from 1983 to 1984, following three years as counsel to the chairman of the Senate Armed Services Committee.