Žučna kiselina-KoA:aminokiselina N-aciltransferaza

Žučna kiselina-KoA:aminokiselina N-aciltransferaza
Identifikatori
EC broj	2.3.1.65
CAS broj	65979-40-0
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Žučna kiselina-KoA:aminokiselina N-aciltransferaza (EC 2.3.1.65, glicin-taurin N-aciltransferaza, amino kiselina N-holoiltransferaza, BAT, glicinska N-holoiltransferaza, BACAT, holil-KoA glicin-taurin N-aciltransferaza, holil-KoA:taurin N-aciltransferaza) je enzim sa sistematskim imenom holoil-KoA:glicin N-holoiltransferaza.^{[1][2][3][4][5][6][7]} Ovaj enzim katalizuje sledeću hemijsku reakciju

holoil-KoA + glicin ${\displaystyle \rightleftharpoons }$ KoA + glikoholat

Ovaj enzim takođe deluje na KoA derivate drugig žučnih kiselina. Taurin i 2-fluoro-beta-alanin mogu da deluju kao supstrati, mada sporije.

Reference

1. Czuba, B. and Vessey, D.A. (1980). „Kinetic characterization of cholyl-CoA glycine-taurine N-acyltransferase from bovine liver”. J. Biol. Chem. 255: 5296-5299. PMID 7372637. 
2. Jordan, T.W., Lee, R. and Lim, W.C. (1980). „Isoelectric focussing of soluble and particulate benzoyl-CoA and cholyl-CoA:amino acid N-acyltransferases from rat liver”. Biochem. Int. 1: 325-330. 
3. Vessey, D.A. (1979). „The co-purification and common identity of cholyl CoA:glycine- and cholyl CoA:taurine-N-acyltransferase activities from bovine liver”. J. Biol. Chem. 254: 2059-2063. PMID 422567. 
4. Johnson, M.R., Barnes, S., Kwakye, J.B. and Diasio, R.B. (1991). „Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver”. J. Biol. Chem. 266: 10227-10233. PMID 2037576. 
5. Falany, C.N., Xie, X., Wheeler, J.B., Wang, J., Smith, M., He, D. and Barnes, S. (2002). „Molecular cloning and expression of rat liver bile acid CoA ligase”. J. Lipid Res. 43: 2062-2071. PMID 12454267. 
6. He, D., Barnes, S. and Falany, C.N. (2003). „Rat liver bile acid CoA:amino acid N-acyltransferase: expression, characterization, and peroxisomal localization”. J. Lipid Res. 44: 2242-2249. PMID 12951368. 
7. O'Byrne, J., Hunt, M.C., Rai, D.K., Saeki, M. and Alexson, S.E. (2003). „The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine”. J. Biol. Chem. 278: 34237-34244. PMID 12810727. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Bile+acid-CoA:amino+acid+N-acyltransferase