Zeaksantin epoksidaza

Zeaksantin epoksidaza
Identifikatori
EC broj	1.14.13.90
CAS broj	149718-34-3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Zeaksantin epoksidaza (EC 1.14.13.90, Zea-epoksidaza) je enzim sa sistematskim imenom zeaksantin,NAD(P)H:kiseonik oksidoreduktaza.^{[1][2][3][4][5][6][7]} Ovaj enzim katalizuje sledeću hemijsku reakciju

zeaksantin + 2 NAD(P)H + 2 H⁺ + 2 O₂ ${\displaystyle \rightleftharpoons }$ violaksantin + 2 NAD(P)⁺ + 2H₂O (sveukupna reakcija)

(1a) zeaksantin + NAD(P)H + H⁺ + O₂ ${\displaystyle \rightleftharpoons }$ antheraksantin + NAD(P)⁺ + H₂O

(1b) antheraksantin + NAD(P)H + H⁺ + O₂ ${\displaystyle \rightleftharpoons }$ violaksantin + NAD(P)⁺ + H₂O

Ovaj enzim je flavoprotein (FAD). On je aktivan pri slabom svetlu.

Reference

1. Buch, K., Stransky, H. and Hager, A. (1995). „FAD is a further essential cofactor of the NAD(P)H and O₂-dependent zeaxanthin-epoxidase”. FEBS Lett. 376: 45-48. PMID 8521963. 
2. Bugos, R.C., Hieber, A.D. and Yamamoto, H.Y. (1998). „Xanthophyll cycle enzymes are members of the lipocalin family, the first identified from plants”. J. Biol. Chem. 273: 15321-15324. PMID 9624110. 
3. Thompson, A.J., Jackson, A.C., Parker, R.A., Morpeth, D.R., Burbidge, A. and Taylor, I.B. (2000). „Abscisic acid biosynthesis in tomato: regulation of zeaxanthin epoxidase and 9-cis-epoxycarotenoid dioxygenase mRNAs by light/dark cycles, water stress and abscisic acid”. Plant Mol. Biol. 42: 833-845. PMID 10890531. 
4. Hieber, A.D., Bugos, R.C. and Yamamoto, H.Y. (2000). „Plant lipocalins: violaxanthin de-epoxidase and zeaxanthin epoxidase”. Biochim. Biophys. Acta 1482: 84-91. PMID 11058750. 
5. Frommolt, R., Goss, R. and Wilhelm, C. (2001). „The de-epoxidase and epoxidase reactions of Mantoniella squamata (Prasinophyceae) exhibit different substrate-specific reaction kinetics compared to spinach”. Planta 213: 446-456. PMID 11506368. 
6. Frommolt, R., Goss, R. and Wilhelm, C. (2001). „Erratum Report. The de-epoxidase and epoxidase reactions of Mantoniella squamata (Prasinophyceae) exhibit different substrate-specific reaction kinetics compared to spinach”. Planta 213: 492-492. PMID 11506368. 
7. Matsubara, S., Morosinotto, T., Bassi, R., Christian, A.L., Fischer-Schliebs, E., Luttge, U., Orthen, B., Franco, A.C., Scarano, F.R., Forster, B., Pogson, B.J. and Osmond, C.B. (2003). „Occurrence of the lutein-epoxide cycle in mistletoes of the Loranthaceae and Viscaceae”. Planta 217: 868-879. PMID 12844265. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Spoljašnje veze

• MeSH Zeaxanthin+epoxidase