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Urejna karboksilaza
Identifikatori
EC broj	6.3.4.6
CAS broj	9058-98-4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Urejna karboksilaza (EC 6.3.4.6, ureaza (ATP hidrolizacija), urejna karboksilaza (hidrolizacija), ATP-urejna amidolijaza, urejna amidolijaza, UALaza, UCA) je enzim sa sistematskim imenom ureja:karbon-dioksid ligaza (formira ADP).^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + ureja + HCO₃^-

\rightleftharpoons

ADP + fosfat + ureja-1-karboksilat

Ovaj enzim je biotinilni protein.

Reference

↑ Roon, R.J. and Levenberg, B. (1970). „ATP-Urea amidolyase (ADP) (Candida utilis)”. Methods Enzymol. 17A: 317-324.
↑ Roon, R.J. and Levenberg, B. (1972). „Urea amidolyase. I. Properties of the enzyme from Candida utilis”. J. Biol. Chem. 247: 4107-4113. PMID 4556303.
↑ Sumrada, R.A. and Cooper, T.G. (1982). „Urea carboxylase and allophanate hydrolase are components of a multifunctional protein in yeast”. J. Biol. Chem. 257: 9119-9127. PMID 6124544.
↑ Kanamori, T., Kanou, N., Atomi, H. and Imanaka, T. (2004). „Enzymatic characterization of a prokaryotic urea carboxylase”. J. Bacteriol. 186: 2532-2539. PMID 15090492.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Urea+carboxylase

[1] Roon, R.J. and Levenberg, B. (1970). „ATP-Urea amidolyase (ADP) (Candida utilis)”. Methods Enzymol. 17A: 317-324.

[2] Roon, R.J. and Levenberg, B. (1972). „Urea amidolyase. I. Properties of the enzyme from Candida utilis”. J. Biol. Chem. 247: 4107-4113. PMID 4556303.

[3] Sumrada, R.A. and Cooper, T.G. (1982). „Urea carboxylase and allophanate hydrolase are components of a multifunctional protein in yeast”. J. Biol. Chem. 257: 9119-9127. PMID 6124544.

[4] Kanamori, T., Kanou, N., Atomi, H. and Imanaka, T. (2004). „Enzymatic characterization of a prokaryotic urea carboxylase”. J. Bacteriol. 186: 2532-2539. PMID 15090492.

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