Urat oksidaza

Urat oksidaza
Tetramer urat oksidaze (Aspergillus flavus)
Identifikatori
EC broj	1.7.3.3
CAS broj	2594291
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Urat oksidaza (EC 1.7.3.3, urinsko kiselinska oksidaza, urikaza, urikaza II, uratna-oksidaza) je enzim sa sistematskim imenom urat:kiseonik oksidoreduktaza.^{[1][2][3][4][5][6]} Ovaj enzim katalizuje sledeću hemijsku reakciju

urat + O₂ +H₂O ${\displaystyle \rightleftharpoons }$ 5-hidroksiizourat +H₂O₂

Enzimu iz zrna soje, plesni Aspergillus flavus i Bacillus subtilis ne sadrže bakar, niti druge jone prelaznih metala.

Reference

1. London, M. and Hudson, P.B. (1956). „Purification and properties of solubilized uricase”. Biochim. Biophys. Acta 21: 290-298. PMID 13363909. 
2. Mahler, H.R., Hübscher, G. and Baum, H. (1955). „Studies on uricase. I. Preparation, purification, and properties of a cuproprotein”. J. Biol. Chem. 216: 625-641. PMID 13271340. 
3. Robbins, K.C., Barnett, E.L. and Grant, N.H. (1955). „Partial purification of porcine liver uricase”. J. Biol. Chem. 216: 27-35. PMID 13252004. 
4. Kahn, K. and Tipton, P.A. (1998). „Spectroscopic characterization of intermediates in the urate oxidase reaction”. Biochemistry 37: 11651-11659. PMID 9709003. 
5. Colloc'h, N., el Hajji, M., Bachet, B., L'Hermite, G., Schiltz, M., Prange, T., Castro, B. and Mornon, J.-P. (1997). „Crystal structure of the protein drug urate oxidase-inhibitor complex at 2.05 Å resolution”. Nat. Struct. Biol. 4: 947-952. PMID 9360612. 
6. Imhoff, R.D., Power, N.P., Borrok, M.J. and Tipton, P.A. (2003). „General base catalysis in the urate oxidase reaction: evidence for a novel Thr-Lys catalytic diad”. Biochemistry 42: 4094-4100. PMID 12680763. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Urate+oxidase