UDP-N-acetilmuramat dehidrogenaza

UDP-N-acetilmuramat dehidrogenaza
UDP-N-acetilmuramat dehidrogenaza homodimer, Mycobacterium tuberculosis
Identifikatori
EC broj	1.3.1.98
CAS broj	39307-28-3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

UDP-N-acetilmuramat dehidrogenaza (EC 1.3.1.98, MurB reduktaza, UDP-N-acetilenolpiruvoilglukozaminska reduktaza, UDP-N-acetilglukozamin-enoilpiruvatna reduktaza, UDP-GlcNAc-enoilpiruvatna reduktaza, uridin difosfoacetilpiruvoilglukozaminska reduktaza, uridin difosfo-N-acetilglukozamin-enolpiruvatna reduktaza, uridin-5'-difosfo-N-acetil-2-amino-2-dezoksi-3-O-laktilglukoza:NADP-oksidoreduktaza) je enzim sa sistematskim imenom UDP-N-acetilmuramat:NADP⁺ oksidoreduktaza.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-N-acetilmuramat + NADP⁺ ${\displaystyle \rightleftharpoons }$ UDP-N-acetil-3-O-(1-karboksivinil)-D-glukozamin + NADPH + H⁺

Dva supstrata UDP-N-acetilmuramatne dehidrogenaze su UDP-N-acetilmuramat i NADP⁺, doks su njena tri produkta: UDP-N-acetil-3-O-(1-karboksivinil)-D-glukozamin, NADPH, i H⁺.

Natrijum ditionit, natrijum borohidrid, i u manjoj meri, NADH, mogu da zamene NADPH.

Reference

1. Taku, A. and Anwar, R.A. (1973). „Biosynthesis of uridine diphospho-N-acetylmuramic acid. IV. Activation of uridine diphospho-N-acetylenolpyruvylglucosamine reductase by monovalent cations”. J. Biol. Chem. 248: 4971-1976. PMID 4717533. 
2. Taku, A., Gunetileke, K.G. and Anwar, R.A. (1970). „Biosynthesis of uridine diphospho-N-acetylmuramic acid. 3. Purification and properties of uridine diphospho-N-acetylenolpyruvyl-glucosamine reductase”. J. Biol. Chem. 245: 5012-5016. PMID 4394163. 
3. van Heijenoort, J. (2001). „Recent advances in the formation of the bacterial peptidoglycan monomer unit”. Nat. Prod. Rep. 18: 503-519. PMID 11699883. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH UDP-N-acetylmuramate+dehydrogenase