UDP-N-acetilmuramat-L-alaninska ligaza

UDP-N-acetilmuramat-L-alaninska ligaza
Identifikatori
EC broj	6.3.2.8
CAS broj	9023-52-3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

UDP-N-acetilmuramat-L-alaninska ligaza (EC 6.3.2.8, MurC sintetaza, UDP-N-acetilmuramoil-L-alanin sintetaza, uridin difosfo-N-acetilmuramoilalanin sintetaza, UDP-N-acetilmuramoilalanin sintetaza, enzim dodavanja L-alanina, UDP-acetilmuramil-L-alanin sintetaza, UDPMurNAc-L-alanin sintetaza, L-Ala ligaza, uridin difosfat N-acetilmuramat:L-alanin ligaza, uridin 5'-difosfat-N-acetilmuramil-L-alanin sintetaza, uridin-difosfat-N-acetilmuramat:L-alanin ligaza, UDP-MurNAc:L-alanin ligaza, enzim dodavanja alanina, UDP-N-acetilmuramil:L-alanin ligaza) je enzim sa sistematskim imenom UDP-N-acetilmuramat:L-alanin ligaza (formira ADP).^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + UDP-N-acetilmuramat + L-alanin ${\displaystyle \rightleftharpoons }$ ADP + fosfat + UDP-N-acetilmuramoil-L-alanin

Ovaj enzim učestvuje u sintezi peptida ćelijskog zida.

Reference

1. Ito, E. and Strominger, J.L. (1962). „Enzymatic synthesis of the peptide in bacterial uridine nucleotides. I. Enzymatic addition of L-alanine, D-glutamic acid, and L-lysine”. J. Biol. Chem. 237: 2689-2695. 
2. Nathenson, S.G., Strominger, J.L. and Ito, E. (1964). „Enzymatic synthesis of the peptide in bacterial uridine nucleotides. IV. Purification and properties of D-glutamic acid-adding enzyme”. J. Biol. Chem. 239: 1773-1776. PMID 14213349. 
3. van Heijenoort, J. (2001). „Recent advances in the formation of the bacterial peptidoglycan monomer unit”. Nat. Prod. Rep. 18: 503-519. PMID 11699883. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH UDP-N-acetylmuramate---L-alanine+ligase