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Triptofan-tRNK ligaza
Identifikatori
EC broj	6.1.1.2
CAS broj	9023-44-3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Triptofan-tRNK ligaza (EC 6.1.1.2, triptofanil-tRNK sintetaza, L-triptofan-tRNKTrp ligaza (formira AMP), triptofanol-transfer ribonukleat sintetaza, triptofanil-transfer ribonukleinsko kiselinska sintetaza, triptofanil-transfer RNK sintetaza, triptofanil ribonukleinska sintetaza, triptofanil-transfer ribonukleinska sintetaza, triptofanil-tRNK sintaza, triptofanska translaza, TrpRS) je enzim sa sistematskim imenom L-triptofan:tRNKTrp ligaza (formira AMP).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + L-triptofan + tRNK^Trp

\rightleftharpoons

AMP + difosfat + L-triptofil-tRNK^Trp

Reference

↑ Davie, E.W., Koningsberger, V.V. and Lipmann, F. (1956). „The isolation of a tryptophan-activating enzyme from pancreas”. Arch. Biochem. Biophys. 65: 21-28. PMID 13373404.
↑ Preddie, E.C. (1969). „Tryptophanyl transfer ribonucleic acid synthetase from bovine pancreas. II. The chemically different subunits”. J. Biol. Chem. 244: 3958-3968. PMID 5805407.
↑ Wong, K.K., Meister, A. and Moldave, K. (1959). „Enzymic formation of ribonucleic acid-amino acid from synthetic aminoacyladenylate and ribonucleic acid”. Biochim. Biophys. Acta 36: 531-533. PMID 13845797.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Tryptophan---tRNA+ligase

[1] Davie, E.W., Koningsberger, V.V. and Lipmann, F. (1956). „The isolation of a tryptophan-activating enzyme from pancreas”. Arch. Biochem. Biophys. 65: 21-28. PMID 13373404.

[2] Preddie, E.C. (1969). „Tryptophanyl transfer ribonucleic acid synthetase from bovine pancreas. II. The chemically different subunits”. J. Biol. Chem. 244: 3958-3968. PMID 5805407.

[3] Wong, K.K., Meister, A. and Moldave, K. (1959). „Enzymic formation of ribonucleic acid-amino acid from synthetic aminoacyladenylate and ribonucleic acid”. Biochim. Biophys. Acta 36: 531-533. PMID 13845797.

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