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Treonin-tRNK ligaza
Identifikatori
EC broj	6.1.1.3
CAS broj	9023-46-5
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Treonin-tRNK ligaza (EC 6.1.1.3, treonil-tRNK sintetaza, treonil-transferna ribonukleatna sintetaza, treonil-transferna RNK sintetaza, treonil-transferna ribonukleinsko kiselinska sintetaza, treonilna ribonukleinska sintetaza, treonin-transferna ribonukleatna sintetaza, treoninska translaza, treonil-tRNK sintetaza, TRS) je enzim sa sistematskim imenom L-treonin:tRNKThr ligaza (formira AMP).^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + L-treonin + tRNK^Thr

\rightleftharpoons

AMP + difosfat + L-treonil-tRNK^Thr

Reference

↑ Allen, E.H., Glassman, E. and Schweet, R.S. (1960). „Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes”. J. Biol. Chem. 235: 1061-1067. PMID 13792726.
↑ Holley, R.W., Brunngraber, E.F., Saad, F. and Williams, H.H. (1961). „Partial purification of the threonine- and tyrosine-activating enzymes from rat liver, and the effect of potassium ions on the activity of the tyrosine enzyme”. J. Biol. Chem. 236: 197-199. PMID 13715350.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Threonine---tRNA+ligase

[1] Allen, E.H., Glassman, E. and Schweet, R.S. (1960). „Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes”. J. Biol. Chem. 235: 1061-1067. PMID 13792726.

[2] Holley, R.W., Brunngraber, E.F., Saad, F. and Williams, H.H. (1961). „Partial purification of the threonine- and tyrosine-activating enzymes from rat liver, and the effect of potassium ions on the activity of the tyrosine enzyme”. J. Biol. Chem. 236: 197-199. PMID 13715350.

[1]

[2]