Tetraacildisaharid 4'-kinaza

Tetraacildisaharid 4'-kinaza
Identifikatori
EC broj	2.7.1.130
CAS broj	107309-06-8
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Tetraacildisaharid 4'-kinaza (EC 2.7.1.130, lipidna A 4'-kinaza) je enzim sa sistematskim imenom ATP:2,3,2',3'-tetrakis(3-hidroksitetradekanoil)-D-glukozaminil-beta-D-1,6-glukozaminil-beta-fosfat 4'-O-fosfotransferaza.^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + [2-N,3-O-bis(3-hidroksitetradekanoil)-beta-D-glukozaminil]-(1->6)-[2-N,3-O-bis(3-hidroksitetradekanoil)-beta-D-glukozaminil fosfat] ${\displaystyle \rightleftharpoons }$ ADP + [2-N,3-O-bis(3-hidroksitetradekanoil)-4-O-fosfono-beta-D-glukozaminil]-(1->6)-[2-N,3-O-bis(3-hidroksitetradekanoil)-beta-D-glukozaminil fosfat]

Ovaj enzim učestvuje sa EC 2.3.1.129 (acil-[acil-nosilac- protein]—UDP-N-acetilglukozamin O-aciltransferazom) i EC 2.4.1.182 (lipid-A-disaharidnom sintazom) u biosintezi fosforilisanog glikolipida, lipid A, na spoljašnjoj membrani bakterije Escherichia coli.

Reference

1. Ray, B.L. and Raetz, C.R.H. (1987). „The biosynthesis of gram-negative endotoxin. A novel kinase in Escherichia coli membranes that incorporates the 4′-phosphate of lipid A”. J. Biol. Chem. 262: 1122-1128. PMID 3027079. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Tetraacyldisaccharide+4'-kinase