Tentoksilizin

Tentoksilizin
Identifikatori
EC broj	3.4.24.68
CAS broj	107231-12-9
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Tentoksilizin (EC 3.4.24.68, tetanus neurotoksin) je enzim.^{[1][2][3][4][5]} Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza -Gln⁷⁶-Phe- veze u sinaptobrevinu

Ovaj cinkov enzim proizvodi Clostridium tetani.

Reference

1. Fujii, N., Kimura, K., Yashiki, T., Tsuzuki, K., Moriishi, K., Yokosawa, N., Syuto, B. and Oguma, K. (1992). „A zinc-protease specific domain in botulinum and tetanus neurotoxins”. Microbiol. Intern. 36: 213-220. PMID 1376283. 
2. Schiavo, G., Benfenati, F., Poulain, B., Rossetto, O., Polverino de Laureto, P., DasGupta, B.R. and Montecucco, C. (1992). „Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin”. Nature 359: 832-834. PMID 1331807. 
3. Schiavo, G., Rossetto, O., Santucci, A., DasGupta, B.R. and Montecucco, C. (1992). „Botulinum neurotoxins are zinc proteins”. J. Biol. Chem. 267: 23479-23483. PMID 1429690. 
4. Montecucco, C. and Schiavo, G. (1994). „Mechanism of action of tetanus and botulinum neurotoxins”. Mol. Microbiol. 8: 1-13. PMID 7527117. 
5. Schiavo, G. and Montecucco, C. (1995). „Tetanus and botulism neurotoxins”. Methods Enzymol. 248: 643-652. PMID 7674951. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Tentoxilysin