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Taksadien 5a-hidroksilaza
Identifikatori
EC broj	1.14.99.37
CAS broj	9035-51-2
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Taksadien 5a-hidroksilaza (EC 1.14.99.37, taksadienska 5a-hidroksilaza) je enzim sa sistematskim imenom taksa-4,11-dien,vodonik-donor:kiseonik oksidoreduktaza (5alfa-hidroksilacija).^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju:

taksa-4,11-dien + AH₂ + O₂

\rightleftharpoons

taksa-4(20),11-dien-5alfa-ol + A + H₂O

Ovaj mikrozomalni je zavistan od citohroma P450. On učestvuje u biosintezi diterpenoidnog antineoplastičnog leka Taksola (paklitaksela).

Reference

↑ Hefner, J., Rubenstein, S.M., Ketchum, R.E., Gibson, D.M., Williams, R.M. and Croteau, R. (1996). „Cytochrome P₄₅₀-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5α-ol: the first oxygenation step in taxol biosynthesis”. Chem. Biol. 3: 479-489. PMID 8807878.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Taxadiene+5alpha-hydroxylase

[1] Hefner, J., Rubenstein, S.M., Ketchum, R.E., Gibson, D.M., Williams, R.M. and Croteau, R. (1996). „Cytochrome P₄₅₀-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5α-ol: the first oxygenation step in taxol biosynthesis”. Chem. Biol. 3: 479-489. PMID 8807878.

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