Sumpor dioksigenaza

Sumpor dioksigenaza
Identifikatori
EC broj	1.13.11.18
CAS broj	37256-58-9
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Sumpor dioksigenaza (EC 1.13.11.18, sumporna oksigenaza, sumpor:kiseonik oksidoreduktaza) je enzim sa sistematskim imenom S-sulfanilglutation:kiseonik oksidoreduktaza.^[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

sumpor + O₂ +H₂O ${\displaystyle \rightleftharpoons }$ sulfit + 2 H⁺ (sveukupna reakcija)

(1a) glutation + sumpor ${\displaystyle \rightleftharpoons }$ S-sulfanilglutation (spontana reakcija)

(1b) S-sulfanilglutation + O₂ + H₂O ${\displaystyle \rightleftharpoons }$ glutation + sulfit + 2 H⁺

Ovaj enzim sadrži gvožđe. Glutation (GSH) ima katalitičku ulogu u aktivaciji elemernog sumpora, ali se ne konzumira tokom reakcije.

Reference

1. Suzuki, I. and Silver, M. (1966). „The initial product and properties of the sulfur-oxidizing enzyme of thiobacilli”. Biochim. Biophys. Acta 122: 22-33. PMID 5968172. 
2. Rohwerder, T. and Sand, W. (2003). „The sulfane sulfur of persulfides is the actual substrate of the sulfur-oxidizing enzymes from Acidithiobacillus and Acidiphilium spp”. Microbiology 149: 1699-1710. PMID 12855721. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Sulfur+dioxygenase