Steroid 11b-monooksigenaza

Steroid 11b-monooksigenaza
Identifikatori
EC broj	1.14.15.4
CAS broj	9029-66-7
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Steroid 11b-monooksigenaza (EC 1.14.15.4, steroidna 11beta-hidroksilaza, steroidna 11beta/18-hidroksilaza, oksigenaza, steroid 11beta -mono-) je enzim sa sistematskim imenom steroid,redukovani-adrenal-feredoksin:kiseonik oksidoreduktaza (11beta-hidroksilacija).^{[1][2][3][4][5]} Ovaj enzim katalizuje sledeću hemijsku reakciju:

steroid + redukovani adrenal feredoksin + O₂ ${\displaystyle \rightleftharpoons }$ 11beta-hidroksisteroid + oksidovani adrenal feredoksin + H₂O

Ovaj enzim je hem-tiolatni protein (P-450). On takođe vrši hidroksilaciju steroida u 18-poziciji, i konvertuje 18-hidroksikortikosteron u aldosteron.

Reference

1. Grant, J.K. and Brownie, A.C. (1955). „The role of fumarate and TPN in steroid enzymic 11β-hydroxylation”. Biochim. Biophys. Acta 18: 433-434. PMID 13276417. 
2. Hayano, M. and Dorfman, R.I. (1954). „On the mechanism of the C-11β-hydroxylation of steroids”. J. Biol. Chem. 211: 227-235. PMID 13211659. 
3. Tomkins, G.M., Michael, P.J. and Curran, J.F. (1957). „Studies on the nature of steroid 11-β hydroxylation”. Biochim. Biophys. Acta 23: 655-656. PMID 13426185. 
4. Yanagibashi, K., Haniu, M., Shively, J.E., Shen, W.H. and Hall, P. (1986). „The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11β-, 18-hydroxylation, and aldehyde synthesis”. J. Biol. Chem. 261: 3556-3562. PMID 3485096. 
5. Zuidweg, M.H.J. (1968). „Hydroxylation of Reichstein's compound S with cell-free preparations from Curvularia lunata”. Biochim. Biophys. Acta 152: 144-158. PMID 4967077. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Steroid+11beta-monooxygenase