Seralizin

Seralizin
Identifikatori
EC broj	3.4.24.40
CAS broj	70851-98-8
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Seralizin (EC 3.4.24.40, Pseudomonas aeruginosa alkalinska proteinaza, Escherichia freundii proteinaza, Serratia marcescens ekstraćelijska proteinaza, Serratia marcescens metaloproteinaza, Pseudomonas aeruginosa alk. proteaza, Serratia marcescens metaloproteaza) je enzim.^{[1][2][3][4][5][6][7][8]} Ovaj enzim katalizuje sledeću hemijsku reakciju

Preferentno razlaganje veza sa hidrofobnim ostacima u P1'

Ova endopeptidaza je prisutna u Pseudomonas aeruginosa, Escherichia freundii, Serratia marcescens i Erwinia chrysanthemi.

Reference

1. Morihara, K., Tsuzuki, H. and Oka, T. (1968). „Comparison of the specificities of various neutral proteinases from microorganisms”. Arch. Biochem. Biophys. 123: 572-588. PMID 4967801. 
2. Morihara, K., Tsuzuki, H. and Oka, T. (1973). „On the specificity of Pseudomonas aeruginosa alkaline proteinase with synthetic peptides”. Biochim. Biophys. Acta 309: 414-429. PMID 4199986. 
3. Nakajima, M., Mizusawa, K. and Yoshida, F. (1974). „Purification and properties of an extracellular proteinase of psychrophilic Escherichia freundii”. Eur. J. Biochem. 44: 87-96. PMID 4212288. 
4. Decedue, C.J., Broussard, E.A., II, L arson, A.D. and Braymer, H.D. (1979). „Purification and characterization of the extracellular proteinase of Serratia marcescens”. Biochim. Biophys. Acta 569: 293-301. PMID 383155. 
5. Doerr, M. and Traub, W.H. (1984). „Purification and characterization of two Serratia marcescens proteases”. Zentralbl. Bakteriol., Mikrobiol. Hyg. Ser. A 257: 6-19. PMID 6380155. 
6. Nakahama, K., Yoshimura, K., Marumoto, R., Kikuchi, M., Lee, I.S., Hase, T. and Matsubara, H. (1986). „Cloning and sequencing of Serratia protease gene”. Nucleic Acids Res. 14: 5843-5856. PMID 3016665. 
7. Dahler, G.S., Barras, F. and Keen, N.T. (1990). „Cloning of genes encoding extracellular metalloproteases from Erwinia chrysanthemi EC16”. J. Bacteriol. 172: 5803-5815. PMID 2211513. 
8. Okuda, K., Morihara, K., Atsumi, Y., Takeuchi, H., Kawamoto, S., Kawasaki, H., Suzuki, K. and Fukushima, J. (1990). „Complete nucleotide sequence of the structural gene for alkaline proteinase from Pseudomonas aeruginosa IFO 3455”. Infect. Immun. 58: 4083-4088. PMID 2123832. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Serralysin