Ribozilpirimidinska nukleozidaza

Ribozilpirimidinska nukleozidaza
Identifikatori
EC broj	3.2.2.8
CAS broj	37288-60-1
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Ribozilpirimidinska nukleozidaza (EC 3.2.2.8, N-ribozilpirimidinska nukleozidaza, pirimidinska nukleozidaza, N-ribozilpirimidinska ribohidrolaza, pirimidinska nukleozidna hidrolaza, RihB, YeiK, nukleozidna ribohidrolaza) je enzim sa sistematskim imenom pirimidin-nukleozidna ribohidrolaza.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

pirimidinski nukleozid + H₂O ${\displaystyle \rightleftharpoons }$ D-riboza + pirimidinska baza

Ovaj enzim takođe u manjoj meri hidrolizuje purin D-ribonukleozide. 2'-, 3'- i 5'-dezoksinukleozidi nisu supstrati.

Reference

1. Terada, M., Tatibana, M. and Hayaishi, O. (1967). „Preparation and properties of nucleoside hydrolase from Pseudomonas fluorescens”. J. Biol. Chem. 242: 5578-5585. PMID 12325375. 
2. Petersen, C. and Møller, L.B. (2001). „The RihA, RihB, and RihC ribonucleoside hydrolases of Escherichia coli. Substrate specificity, gene expression, and regulation”. J. Biol. Chem. 276: 884-894. PMID 11027694. 
3. Giabbai, B. and Degano, M. (2004). „Cloning, purification, crystallization and X-ray analysis of the Escherichia coli pyrimidine nucleoside hydrolase YeiK”. Acta Crystallogr. D Biol. Crystallogr. 60: 524-527. PMID 14993681. 
4. Giabbai, B. and Degano, M. (2004). „Crystal structure to 1.7 Å of the Escherichia coli pyrimidine nucleoside hydrolase YeiK, a novel candidate for cancer gene therapy”. Structure 12: 739-749. PMID 15130467. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Ribosylpyrimidine+nucleosidase