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Regulator G-proteinske signalizacije 12
Dostupne strukture
	2EBZ, 2KV8
Identifikatori
Simboli	RGS12; DKFZp761K1617; DKFZp761K1817
Vanjski ID	OMIM: 602512 MGI: 1918979 HomoloGene: 2195 GeneCards: RGS12 Gene
Ontologija gena
Molekulska funkcija	• aktivnost receptorskog signalnog proteina; • aktivnost GTPaznog aktivatora;
Ćelijska komponenta	• kondenzovani nuklearni hromozom; • nukleus; • nukleolus;
Biološki proces	• transkripcija s DNK šablonom; • regulacija signalnog puta G-protein spregnutog receptora; • prenos intraćelijskog signala;
Pregled RNK izražavanja
	podaci
Ortolozi

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Regulator G-proteinske signalizacije 12 je protein koji je kod ljudi kodiran RGS12 genom.^[1]^[2]

Ovaj gen kodira člana familje 'regulatora G proteinske signalizacije' (RGS). Taj protein deluje kao aktivirajući protein guanozin trifosfataze (GTPaza), i kao transkripcioni represor. Smatra se da on učestuvuje u tumorigenezi. Poznate su višestruke transkriptne varijante koje kodiraju distinktne izoforme. Druge alternativno splajsovane varijante su bile opisane, ali njihova biološka svojstva nisu određena.^[2]

Interakcije

RGS12 formira interakcije sa GNAI1^[3] i GNAI3.^[3]

Reference

↑ Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (August 1998). „GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain”. J Biol Chem 273 (28): 17749–55. DOI:10.1074/jbc.273.28.17749. PMID 9651375.
↑ ^2,0 ^2,1 „Entrez Gene: RGS12 regulator of G-protein signalling 12”.
↑ ^3,0 ^3,1 Kimple, R J; De Vries L; Tronchère H; Behe C I; Morris R A; Gist Farquhar M; Siderovski D P (August 2001). „RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity”. J. Biol. Chem. (United States) 276 (31): 29275–81. DOI:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333.

Literatura

Frohme M, Scharm B, Delius H, et al. (2000). „Use of representational difference analysis and cDNA arrays for transcriptional profiling of tumor tissue.”. Ann. N. Y. Acad. Sci. 910: 85–104; discussion 104–5. DOI:10.1111/j.1749-6632.2000.tb06703.x. PMID 10911908.
Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery.”. Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548.
Snow BE, Antonio L, Suggs S, et al. (1997). „Molecular cloning and expression analysis of rat Rgs12 and Rgs14.”. Biochem. Biophys. Res. Commun. 233 (3): 770–7. DOI:10.1006/bbrc.1997.6537. PMID 9168931.
Chatterjee TK, Fisher RA (2000). „Novel alternative splicing and nuclear localization of human RGS12 gene products.”. J. Biol. Chem. 275 (38): 29660–71. DOI:10.1074/jbc.M000330200. PMID 10869340.
Schiff ML, Siderovski DP, Jordan JD, et al. (2001). „Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel.”. Nature 408 (6813): 723–7. DOI:10.1038/35047093. PMID 11130074.
Kimple RJ, De Vries L, Tronchère H, et al. (2001). „RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity.”. J. Biol. Chem. 276 (31): 29275–81. DOI:10.1074/jbc.M103208200. PMID 11387333.
Snow BE, Brothers GM, Siderovski DP (2002). „Molecular cloning of regulators of G-protein signaling family members and characterization of binding specificity of RGS12 PDZ domain.”. Meth. Enzymol. 344: 740–61. DOI:10.1016/S0076-6879(02)44752-0. PMID 11771424.
Sierra DA, Gilbert DJ, Householder D, et al. (2002). „Evolution of the regulators of G-protein signaling multigene family in mouse and human.”. Genomics 79 (2): 177–85. DOI:10.1006/geno.2002.6693. PMID 11829488.
Chatterjee TK, Fisher RA (2002). „RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression.”. Mol. Cell. Biol. 22 (12): 4334–45. DOI:10.1128/MCB.22.12.4334-4345.2002. PMC 133853. PMID 12024043.
Potocnik U, Glavac D, Ravnik-Glavac M (2003). „Identification of novel genes with somatic frameshift mutations within coding mononucleotide repeats in colorectal tumors with high microsatellite instability.”. Genes Chromosomes Cancer 36 (1): 48–56. DOI:10.1002/gcc.10141. PMID 12461749.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jin J, Smith FD, Stark C, et al. (2004). „Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.”. Curr. Biol. 14 (16): 1436–50. DOI:10.1016/j.cub.2004.07.051. PMID 15324660.
Yang S, Li YP (2007). „RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro.”. J. Bone Miner. Res. 22 (1): 45–54. DOI:10.1359/jbmr.061007. PMC 3559086. PMID 17042716.

[pmid9651375-1] Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (August 1998). „GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain”. J Biol Chem 273 (28): 17749–55. DOI:10.1074/jbc.273.28.17749. PMID 9651375.

[entrez-2] 2,0 ^2,1 „Entrez Gene: RGS12 regulator of G-protein signalling 12”.

[pmid11387333-3] 3,0 ^3,1 Kimple, R J; De Vries L; Tronchère H; Behe C I; Morris R A; Gist Farquhar M; Siderovski D P (August 2001). „RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity”. J. Biol. Chem. (United States) 276 (31): 29275–81. DOI:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333.

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