Protein geranilgeraniltransferaza tip I

Protein geranilgeraniltransferaza tip I
Identifikatori
EC broj	2.5.1.59
CAS broj	135371-29-8
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Protein geranilgeraniltransferaza tip I (EC 2.5.1.59, GGTase-I, GGTaseI) je enzim sa sistematskim imenom geranilgeranil-difosfat:protein-cistein geraniltransferaza.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

geranilgeranil difosfat + protein-cistein ${\displaystyle \rightleftharpoons }$ S-geranilgeranil-protein + difosfat

Ovaj enzim zajedno sa proteinskom farneziltransferazom (EC 2.5.1.58) i proteinskom geranilgeraniltransferazom tip II (EC 2.5.1.60) sačinjava proteinsku preniltransferaznu familiju enzima.

Reference

1. Casey, P.J. and Seabra, M.C. (1996). „Protein prenyltransferases”. J. Biol. Chem. 271: 5289-5292. PMID 8621375. 
2. Zhang, F.L. and Casey, P.J. (1996). „Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I”. Biochem. J. 320: 925-932. PMID 9003382. 
3. Gibbs, R.A. (1998). „Prenyl transfer and the enzymes of terpenoid and steroid biosynthesis”. u: Sinnott, M.. Comprehensive Biological Catalysis. A Mechanistic Reference. 1. San Diego, CA: Academic Press. str. 31-118. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

• Gibbs, R.A. (1998). „Prenyl transfer and the enzymes of terpenoid and steroid biosynthesis”. u: Sinnott, M.. Comprehensive Biological Catalysis. A Mechanistic Reference. 1. San Diego, CA: Academic Press. str. 31-118. 

Vanjske veze

• MeSH Protein+geranylgeranyltransferase+type+I