Protein N-acetilglukozaminiltransferaza

Protein N-acetilglukozaminiltransferaza
Identifikatori
EC broj	2.4.1.94
CAS broj	72319-34-7
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Protein N-acetilglukozaminiltransferaza (EC 2.4.1.94, uridin difosfoacetilglukozamin-protein acetilglukozaminiltransferaza, uridin difosfo-N-acetilglukozamin:polipeptid beta-N-acetilglukozaminiltransferaza, N-acetilglukozaminiltransferaza I) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:(protein)-L-asparagin beta-N-acetil-D-glukozaminil-transferaza.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-N-acetil-D-glukozamin + [protein]-L-asparagin ${\displaystyle \rightleftharpoons }$ UDP + [protein]-N⁴-(N-acetil-D-glukozaminil)-L-asparagin

Akceptor je asparaginski ostatak u sequenci oblika Asn-Xaa-Thr or Asn-Xaa-Ser.

Reference

1. Khalkhali, Z. and Marshall, R.D. (1975). „Glycosylation of ribonuclease A catalysed by rabbit liver extracts”. Biochem. J. 146: 299-307. PMID 1156375. 
2. Khalkhali, Z. and Marshall, R.D. (1976). „UDP-N-acetyl-D-glucosamine-asparagine sequon N-acetyl-β-D-glucosaminyl-transferase-activity in human serum”. Carbohydr. Res. 49: 455-473. PMID 986874. 
3. Khalkhali, Z., Marshall, R.D., Reuvers, F., Habets-Willems, C. and Boer, P. (1976). „Glycosylation in vitro of an asparagine sequon catalysed by preparations of yeast cell membranes”. Biochem. J. 160: 37-41. PMID 795426. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Protein+N-acetylglucosaminyltransferase