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Plazmepsin II
Identifikatori
EC broj	3.4.23.39
CAS broj	159447-18-4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Plazmepsin II (EC 3.4.23.39, aspartinska hemoglobinaza II, PFAPD) je enzim.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza veza koje povezuju pojedine hidrofobne ostatke hemoglobina ili globina. Takođe dolazi do razlaganja malih molekula, kao što su Ala-Leu-Glu-Arg-Thr-Phe-Phe(NO₂)-Ser-Phe-Pro-Thr

Ovaj enzim je pristan u malarijskom organizmu, Plasmodium.

Reference

↑ Dame, J.B., Reddy, G.R., Yowell, C.A., Dunn, B.M., Kay, J. and Berry, C. (1994). „Sequence, expression and modelled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum”. Mol. Biochem. Parasitol. 64: 177-190. PMID 7935597.
↑ Gluzman, I.Y., Francis, S.E., Oksman, A., Smith, C.E., Duffin, K.L. and Goldberg, D.E. (1994). „Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway”. J. Clin. Invest. 93: 1602-1608. PMID 8163662.
↑ Hill, J., Tyas, L., Phylip, L.H., Kay, J., Dunn, B.M. and Berry, C. (1994). „High level expression and characterisation of plasmepsin II, an aspartic proteinase from Plasmodium falciparum”. FEBS Lett. 352: 155-158. PMID 7925966.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Plasmepsin+II

[1] Dame, J.B., Reddy, G.R., Yowell, C.A., Dunn, B.M., Kay, J. and Berry, C. (1994). „Sequence, expression and modelled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum”. Mol. Biochem. Parasitol. 64: 177-190. PMID 7935597.

[2] Gluzman, I.Y., Francis, S.E., Oksman, A., Smith, C.E., Duffin, K.L. and Goldberg, D.E. (1994). „Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway”. J. Clin. Invest. 93: 1602-1608. PMID 8163662.

[3] Hill, J., Tyas, L., Phylip, L.H., Kay, J., Dunn, B.M. and Berry, C. (1994). „High level expression and characterisation of plasmepsin II, an aspartic proteinase from Plasmodium falciparum”. FEBS Lett. 352: 155-158. PMID 7925966.

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