Peptidiltransferaza

Peptidiltransferaza
Identifikatori
EC broj 2.3.2.12
CAS broj 9059-29-4
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Peptidiltransferaza (EC 2.3.2.12, transpeptidaza, ribosomalna peptidiltransferaza) je enzim sa sistematskim imenom peptidil-tRNK:aminoacil-tRNK N-peptidiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

peptidil-tRNK1 + aminoacil-tRNK2 tRNK1 + peptidil(aminoacil-tRNK2)

Ovaj enzim je ribozim. Dve neekvivantne ribonukleoproteinske podjednice deluju na neusaglažen način pri peptidnoj elongaciji.

Reference

  1. Rychlik, I. (1966). „Release of lysine peptides by puromycin from polylysyl-transfer ribonucleic acid in the presence of ribosomes”. Biochim. Biophys. Acta 114: 425-427. PMID 5329275. 
  2. Rychlik, I., Cerná, J., Chládek, S., Zemlicka, J. and Haladová, Z. (1969). „Substrate specificity of ribosomal peptidyl transferase: 2′(3′)-O-aminoacyl nucleosides as acceptors of the peptide chain on the amino acid site”. J. Mol. Biol. 43: 13-24. PMID 4897787. 
  3. Traut, R.R. and Monro, R.E. (1964). „The puromycin reaction and its relation to protein synthesis”. J. Mol. Biol. 10: 63-72. 
  4. Voorhees, R.M., Weixlbaumer, A., Loakes, D., Kelley, A.C. and Ramakrishnan, V. (2009). „Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome”. Nat. Struct. Mol. Biol. 16: 528-533. PMID 19363482. 

Literatura

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