N-acetilgalaktozamin-6-sulfataza

N-acetilgalaktozamin-6-sulfataza
Identifikatori
EC broj	3.1.6.4
CAS broj	9025-60-9
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

N-acetilgalaktozamin-6-sulfataza (EC 3.1.6.4, hondroitinska sulfataza, hondroitinaza, galaktoza-6-sulfatna sulfataza, acetilgalaktozamin 6-sulfataza, N-acetilgalaktozamin-6-sulfatna sulfataza, N-acetilgalaktozamin 6-sulfataza) je enzim sa sistematskim imenom N-acetil-D-galaktozamin-6-sulfat 6-sulfohidrolaza.^{[1][2][3][4][5]} Ovaj enzim katalizuje sledeću hemijsku reakciju

hidroliza 6-sulfatnih grupa N-acetil-D-galaktozamin 6-sulfatnih jedinica hondroitin sulfata i D-galaktoza 6-sulfatnih jedinica keratan sulfata

Reference

1. Epstein, E.H. and Leventhal, M.E. (1981). „Steroid sulfatase of human leukocytes and epidermis and the diagnosis of recessive X-linked ichthyosis”. J. Clin. Invest. 67: 1257-1262. PMID 6939689. 
2. Glössl, J. and Kresse, H. (1982). „Impaired degradation of keratan sulphate by Morquio A fibroblasts”. Biochem. J. 203: 335-338. PMID 6213226. 
3. Lim, C.T. and Horwitz, A.L. (1981). „Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase”. Biochim. Biophys. Acta 657: 344-355. PMID 7213753. 
4. Sørensen, S.H., Norén, O., Sjöström, H. and Danielsen, E.M. (1982). „Amphiphilic pig intestinal microvillus maltase/glucoamylase. Structure and specificity”. Eur. J. Biochem. 126: 559-568. PMID 6814909. 
5. Yutaka, T., Okada, S., Kato, T., Inui, K. and Yabuchi, H. (1982). „Galactose 6-sulfate sulfatase activity in Morquio syndrome”. Clin. Chim. Acta 122: 169-180. PMID 6809361. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH N-acetylgalactosamine-6-sulfatase