Metilmalonil-KoA dekarboksilaza

Metilmalonil-KoA dekarboksilaza
Trimer metilmalonil-KoA dekarboksilaze (E. coli)
Identifikatori
EC broj	4.1.1.41
CAS broj	37289-44-4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Metilmalonil-KoA dekarboksilaza (EC 4.1.1.41, propionil koenzim A karboksilaza, metilmalonil-koenzim A dekarboksilaza, (S)-2-metil-3-oksopropanoil-KoA karboksilijaza, (S)-metilmalonil-KoA karboksilijaza) je enzim sa sistematskim imenom (S)-metilmalonil-KoA karboksilijaza (formira propanoil-KoA).^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

(S)-metilmalonil-KoA ${\displaystyle \rightleftharpoons }$ propanoil-KoA + CO₂

Enzim iz Veillonella alcalescens je biotinski protein.

Reference

1. Galivan, J.H. and Allen, S.H.G. (1968). „Methylmalonyl coenzyme A decarboxylase. Its role in succinate decarboxylation by Micrococcus lactilyticus”. J. Biol. Chem. 243: 1253-1261. PMID 5646172. 
2. Hilpert, W. and Dimroth, P. (1982). „Conversion of the chemical energy of methylmalonyl-CoA decarboxylation into a Na⁺ gradient”. Nature 296: 584-585. PMID 7070502. 
3. Hoffmann, A., Hilpert, W. and Dimroth, P. (1989). „The carboxyltransferase activity of the sodium-ion-translocating methylmalonyl-CoA decarboxylase of Veillonella alcalescens”. Eur. J. Biochem. 179: 645-650. PMID 2920730. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Spoljašnje veze

• MeSH Methylmalonyl-CoA+decarboxylase