Metilkrotonoil-KoA karboksilaza

Metilkrotonoil-KoA karboksilaza
Identifikatori
EC broj	6.4.1.4
CAS broj	9023-95-4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Metilkrotonoil-KoA karboksilaza (EC 6.4.1.4, metilkrotonil koenzim A karboksilaza, beta-metilkrotonil koenzim A karboksilaza, beta-metilkrotonil KoA karboksilaza, metilkrotonil-KoA karboksilaza) je enzim sa sistematskim imenom 3-metilkrotonoil-KoA:ugljen-dioksid ligaza (formira ADP).^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + 3-metilkrotonoil-KoA + HCO₃^- ${\displaystyle \rightleftharpoons }$ ADP + fosfat + 3-metilglutaconyL-KoA

Ovaj enzim je biotinilni protein.

Reference

1. Knappe, J., Schlegel, H.-G. and Lynen, F. (1961). „Zur biochemischen Funktion des Biotins. I. Die Beteilligung der β-Methyl-crotonyl-Carboxylase an der Bildung von β-Hydroxy-β-methyl-glutaryl-CoA from β-Hydroxy-isovaleryl-CoA”. Biochem. Z. 335: 101-122. PMID 14457200. 
2. Lynen, F., Knappe, J., Lorch, E., Jütting, G., Ringelmann, E. and Lachance, J.-P. (1961). „Zur biochemischen Funktion des Biotins. II. Reinigung und Wirkungsweise der β-Methyl-crotonyl-Carboxlase”. Biochem. Z. 335: 123-166. PMID 14467590. 
3. Rilling, H.C. and Coon, M.J. (1960). „The enzymatic isomerization of α-methylvinylacetyl coenzyme A and the specificity of a bacterial α-methylcrotonyl coenzyme A carboxylase”. J. Biol. Chem. 235: 3087-3092. PMID 13741692. 
4. Vagelos, P. (1971). „Regulation of fatty acid biosynthesis”. Curr. Top. Cell. Regul. 4: 119-166. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Spoljašnje veze

• MeSH Methylcrotonoyl-CoA+carboxylase