Malat dehidrogenaza

Malat dehidrogenaza
Tetramer malat dehidrogenaze (čovjek)
Identifikatori
EC broj	1.1.1.37
CAS broj	9001-64-3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Malat dehidrogenaza (EC 1.1.1.37, L-malat dehidrogenaza, NAD-L-malat dehidrogenaza, malatna kiselina dehidrogenaza, NAD-zavisna malitna dehidrogenaza, NAD-malat dehidrogenaza, NAD-malatna dehidrogenaza, malat (NAD) dehidrogenaza, NAD-specifična malat dehidrogenaza, NAD-vezana malat dehidrogenaza, MDH, L-malat-NAD⁺ oksidoreduktaza) je enzim sa sistematskim imenom (S)-malat:NAD⁺ oksidoreduktaza.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

(S)-malat + NAD⁺ ${\displaystyle \rightleftharpoons }$ oksaloacetat + NADH + H⁺

Takođe oksiduje nekoliko drugih 2-hidroksidikarboksilnih kiselina.

Reference

1. Banaszak, L.J. and Bradshaw, R.A. (1975). „Malate dehydrogenase”. u: Boyer, P.D.. The Enzymes. 11 (3rd izd.). New York: Academic Press. str. 369-396. 
2. Guha, A., Englard, S. and Listowsky, I. (1968). „Beef heart malic dehydrogenases. VII. Reactivity of sulfhydryl groups and conformation of the supernatant enzyme”. J. Biol. Chem. 243: 609-615. PMID 5637713. 
3. McReynolds, M.S. and Kitto, G.B. (1970). „Purification and properties of Drosophila malate dehydrogenases”. Biochim. Biophys. Acta 198: 165-175. PMID 4313528. 
4. Wolfe, R.G. and Nielands, J.B. (1956). „Some molecular and kinetic properties of heart malic dehydrogenase”. J. Biol. Chem. 221: 61-69. PMID 13345798. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Malate+dehydrogenase