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Krotonil-KoA reduktaza
Identifikatori
EC broj	1.3.1.86
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Krotonil-KoA reduktaza (EC 1.3.1.86, butirilna dehidrogenaza, nezasićeni acil-KoA reduktaza, etilenska reduktaza, enoil-koenzim A reduktaza, nezasićeni acil koenzim A reduktaza, butirilni koenzim A dehidrogenaza, kratkolančani acil KoA dehidrogenaza, kratkolančani acil-koenzim A dehidrogenaza, 3-hidroksiacilna KoA reduktaza, butanoil-KoA:(akceptor) 2,3-oksidoreduktaza, CCR) je enzim sa sistematskim imenom butanoil-KoA:NADP⁺ 2,3-oksidoreduktaza.^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

butanoil-KoA + NADP⁺

\rightleftharpoons

(E)-but-2-enoil-KoA + NADPH + H⁺

Ovaj enzim katalizuje reakciju u reverznom smeru. Ovaj enzim iz Streptomyces collinus je specifičan za (E)-but-2-enoil-KoA, i smatra se da formira butanoil-KoA kao početnu jedinicu za biosintezu pravolančanih masnih kiselina.

Reference

↑ Wallace, K.K., Bao, Z.Y., Dai, H., Digate, R., Schuler, G., Speedie, M.K. and Reynolds, K.A. (1995). „Purification of crotonyl-CoA reductase from Streptomyces collinus and cloning, sequencing and expression of the corresponding gene in Escherichia coli”. Eur. J. Biochem. 233: 954-962. PMID 8521864.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Crotonyl-CoA+reductase

[1] Wallace, K.K., Bao, Z.Y., Dai, H., Digate, R., Schuler, G., Speedie, M.K. and Reynolds, K.A. (1995). „Purification of crotonyl-CoA reductase from Streptomyces collinus and cloning, sequencing and expression of the corresponding gene in Escherichia coli”. Eur. J. Biochem. 233: 954-962. PMID 8521864.

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