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Kaspaza-4
Identifikatori
EC broj	3.4.22.57
CAS broj	182762-08-9
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Kaspaza-4 (EC 3.4.22.57, ICErel-II, Ich-2, transkript X, TX, TX proteaza, kaspaza 4, CASP-4) je enzim.^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Neophodno je prisustvo Asp ostatka u P1 poziciji. Preferentno dolazi do razlaganja sekvence Tyr-Val-Ala-Asp-, ali se takođe razlaže Asp-Glu-Val-Asp-

Ovaj enzim pripada familiji inflamatornih kaspaza, koja takođe obuhvata kaspazu-1 (EC 3.4.22.36) i kaspazu-5 (EC 3.4.22.58) kod ljudi i kaspazu-11 (EC 3.4.22.64), kaspazu-12, kaspazu-13 i kaspazu-14 kod miševa.

Reference

↑ Faucheu, C., Diu, A., Chan, A.W., Blanchet, A.M., Miossec, C., Hervé, F., Collard-Dutilleul, V., Gu, Y., Aldape, R.A., Lippke, J.A., Rocher, C., Su, M.S.-S., Livingston, D.J., Hercend, T. and Lalanne, J.-L. (1995). „A novel human protease similar to the interleukin-1β converting enzyme induces apoptosis in transfected cells”. EMBO J. 14: 1914-1922. PMID 7743998.
↑ Kamens, J., Paskind, M., Hugunin, M., Talanian, R.V., Allen, H., Banach, D., Bump, N., Hackett, M., Johnston, C.G., Li, P., Mankovich, J.A., Terranova, M. and Ghayur, T. (1995). „Identification and characterization of ICH-2, a novel member of the interleukin-1β-converting enzyme family of cysteine proteases”. J. Biol. Chem. 270: 15250-15256. PMID 7797510.
↑ Kamada, S., Funahashi, Y. and Tsujimoto, Y. (1997). „Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases”. Cell Death Differ. 4: 473-478. PMID 16465268.
↑ Fassy, F., Krebs, O., Rey, H., Komara, B., Gillard, C., Capdevila, C., Yea, C., Faucheu, C., Blanchet, A.M., Miossec, C. and Diu-Hercend, A. (1998). „Enzymatic activity of two caspases related to interleukin-1β-converting enzyme”. Eur. J. Biochem. 253: 76-83. PMID 9578463.
↑ Martinon, F. and Tschopp, J. (2004). „Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases”. Cell 117: 561-574. PMID 15163405.
↑ Chang, H.Y. and Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821-846. PMID 11104820.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Caspase-4

[1] Faucheu, C., Diu, A., Chan, A.W., Blanchet, A.M., Miossec, C., Hervé, F., Collard-Dutilleul, V., Gu, Y., Aldape, R.A., Lippke, J.A., Rocher, C., Su, M.S.-S., Livingston, D.J., Hercend, T. and Lalanne, J.-L. (1995). „A novel human protease similar to the interleukin-1β converting enzyme induces apoptosis in transfected cells”. EMBO J. 14: 1914-1922. PMID 7743998.

[2] Kamens, J., Paskind, M., Hugunin, M., Talanian, R.V., Allen, H., Banach, D., Bump, N., Hackett, M., Johnston, C.G., Li, P., Mankovich, J.A., Terranova, M. and Ghayur, T. (1995). „Identification and characterization of ICH-2, a novel member of the interleukin-1β-converting enzyme family of cysteine proteases”. J. Biol. Chem. 270: 15250-15256. PMID 7797510.

[3] Kamada, S., Funahashi, Y. and Tsujimoto, Y. (1997). „Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases”. Cell Death Differ. 4: 473-478. PMID 16465268.

[4] Fassy, F., Krebs, O., Rey, H., Komara, B., Gillard, C., Capdevila, C., Yea, C., Faucheu, C., Blanchet, A.M., Miossec, C. and Diu-Hercend, A. (1998). „Enzymatic activity of two caspases related to interleukin-1β-converting enzyme”. Eur. J. Biochem. 253: 76-83. PMID 9578463.

[5] Martinon, F. and Tschopp, J. (2004). „Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases”. Cell 117: 561-574. PMID 15163405.

[6] Chang, H.Y. and Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821-846. PMID 11104820.

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