Karboksipeptidaza M

Karboksipeptidaza M
Identifikatori
EC broj	3.4.17.12
CAS broj	120038-28-0
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Karboksipeptidaza M (EC 3.4.17.12, CPM) je enzim.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Odvajanje C-terminalnih argininskih i lizinskih ostataka sa polipeptida

Ovaj membranski enzim je optimalno aktivan pri neutralnom pH.

Reference

1. Skidgel, R.A. (1988). „Basic carboxypeptidases: Regulators of peptide hormone activity”. Trends Pharmacol. Sci. 9: 303-304. PMID 3074547. 
2. Deddish, P.A., Skidgel, R.A. and Erdös, E.G. (1989). „Enhanced Co²⁺ activation and inhibitor binding of carboxypeptidase M at low pH”. Biochem. J. 261: 289-291. PMID 2775217. 
3. Skidgel, R.A., Davis, R.M. and Tan, F. (1989). „Human carboxypeptidase M. Purification and characterization of membrane-bound carboxypeptidase that cleaves peptide hormones”. J. Biol. Chem. 264: 2236-2241. PMID 2914904. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Carboxypeptidase+M