Kalpain-3

Kalpain-3
Identifikatori
EC broj	3.4.22.54
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Kalpain-3 (EC 3.4.22.54, p94, kalpain p94, CAPN3, mišićni kalpain, kalpain 3, kalcijumom aktivirana neutralna proteinaza 3, mišićno specifična kalcijumom aktivirana neutralna proteaza 3, CANP 3, kalpain L3) je enzim.^{[1][2][3][4][5]} Ovaj enzim katalizuje sledeću hemijsku reakciju

Endopeptidazazno dejstvo sa širokom specifičnošću

Ovaj od Ca²⁺ zavistan enzim je prisutan u skeletalnim mišićima.

Reference

1. Sorimachi, H., Imajoh-Ohmi, S., Emori, Y., Kawasaki, H., Ohno, S., Minami, Y. and Suzuki, K. (1989). „Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and μ-types. Specific expression of the mRNA in skeletal muscle”. J. Biol. Chem. 264: 20106-20111. PMID 2555341. 
2. Sorimachi, H., Kinbara, K., Kimura, S., Takahashi, M., Ishiura, S., Sasagawa, N., Sorimachi, N., Shimada, H., Tagawa, K., Maruyama, K. and Suzuki, K. (1995). „Muscle-specific calpain, p94, responsible for limb girdle muscular dystrophy type 2A, associates with connectin through IS2, a p94-specific sequence”. J. Biol. Chem. 270: 31158-31162. PMID 8537379. 
3. Rey, M.A. and Davies, P.L. (2002). „The protease core of the muscle-specific calpain, p94, undergoes Ca²⁺-dependent intramolecular autolysis”. FEBS Lett. 532: 401-406. PMID 12482600. 
4. García Díaz, B.E., Gauthier, S. and Davies, P.L. (2006). „Ca²⁺ dependency of calpain 3 (p94) activation”. Biochemistry 45: 3714-3722. PMID 16533054. 
5. Ono, Y., Torii, F., Ojima, K., Doi, N., Yoshioka, K., Kawabata, Y., Labeit, D., Labeit, S., Suzuki, K., Abe, K., Maeda, T. and Sorimachi, H. (2006). „Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system”. J. Biol. Chem. 281: 18519-18531. PMID 16627476. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Calpain-3