IMP dehidrogenaza

IMP dehidrogenaza
Struktura IMP dehidrogenaze
Identifikatori
EC broj	1.1.1.205
CAS broj	9028-93-7
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

IMP dehidrogenaza (EC 1.1.1.205, inozin-5'-fosfat dehidrogenaza, inozinska kiselina dehidrogenaza, inozinat dehidrogenaza, inozin 5'-monofosfat dehidrogenaza, inozin monofosfat dehidrogenaza, IMP oksidoreduktaza, inozin monofosfat oksidoreduktaza) je enzim sa sistematskim imenom IMP:NAD⁺ oksidoreduktaza.^[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

IMP + NAD⁺ +H₂O ${\displaystyle \rightleftharpoons }$ XMP + NADH + H⁺

Ovaj enzim deluje na hidroksi grupu hidratisanog derivata supstrata.

Reference

1. Magasanik, B., Moyed, H.S. and Gehring, L.B. (1957). „Enzymes essential for the biosynthesis of nucleic acid guanine; inosine 5′-phosphate dehydrogenase of Aerobacter aerogenes”. J. Biol. Chem. 226: 339-350. PMID 13428767. 
2. Turner, J.F. and King, J.E. (1961). „Inosine 5-phosphate dehydrogenase of pea seeds”. Biochem. J. 79: 147-147. PMID 13778733. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH IMP+dehydrogenase