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Holoil-KoA hidrolaza
Identifikatori
EC broj	3.1.2.27
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Holoil-KoA hidrolaza (EC 3.1.2.27, PTE-2, holoil-koenzim A tioesteraza, henodezoksiholoil-koenzim A tioesteraza, peroksizomalna acil-KoA tioesteraza 2) je enzim sa sistematskim imenom holoil-KoA hidrolaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

holoil-KoA + H₂O

\rightleftharpoons

holat + KoA

Ovaj enzim takođe deluje na henodezoksiholoil-KoA i u manjoj meri na acil-KoA lanaca kratke i srednje dužine.

Reference

↑ Hunt, M.C., Solaas, K., Kase, B.F. and Alexson, S.E. (2002). „Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism”. J. Biol. Chem. 277: 1128-1138. PMID 11673457.
↑ Solaas, K., Sletta, R.J., Soreide, O. and Kase, B.F. (2000). „Presence of choloyl- and chenodeoxycholoyl-coenzyme A thioesterase activity in human liver”. Scand. J. Clin. Lab. Invest. 60: 91-102. PMID 10817395.
↑ Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137-174. PMID 12543708.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

MeSH Choloyl-CoA+hydrolase

[1] Hunt, M.C., Solaas, K., Kase, B.F. and Alexson, S.E. (2002). „Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism”. J. Biol. Chem. 277: 1128-1138. PMID 11673457.

[2] Solaas, K., Sletta, R.J., Soreide, O. and Kase, B.F. (2000). „Presence of choloyl- and chenodeoxycholoyl-coenzyme A thioesterase activity in human liver”. Scand. J. Clin. Lab. Invest. 60: 91-102. PMID 10817395.

[3] Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137-174. PMID 12543708.

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