Hinin 3-monooksigenaza

Hinin 3-monooksigenaza
Identifikatori
EC broj	1.14.13.67
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Hinin 3-monooksigenaza (EC 1.14.13.67, hininska 3-hidroksilaza) je enzim sa sistematskim imenom hinin,NADPH:kiseonik oksidoreduktaza.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

hinin + NADPH + H⁺ + O₂ ${\displaystyle \rightleftharpoons }$ 3-hidroksihinin + NADP⁺ + H₂O

Reference

1. Relling, M.V., Evans, R., Dass, C., Desiderio, D.M. and Nemec, J. (1992). „Human cytochrome P₄₅₀ metabolism of teniposide and etoposide”. J. Pharmacol. Exp. Ther. 261: 491-496. PMID 1578365. 
2. Zhang, H., Coville, P.F., Walker, R.J., Miners, J.O., Birkett, D.J. and Wanwimolruk, S. (1997). „Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine”. Br. J. Clin. Pharmacol. 43: 245-252. PMID 9088578. 
3. Zhao, X.-J., Kawashiro, T. and Ishizaki, T. (1998). „Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P₄₅₀3A4 involvement in their major metabolic pathways”. Drug Metab. Dispos. 26: 188-191. PMID 9456308. 
4. Zhao, X.-J., Yokoyama, H., Chiba, K., Wanwimolruk, S. and Ishizaki, T. (1996). „Identification of human cytochrome P₄₅₀ isoforms involved in the 3-hydroxylation of quinine by human liver microsomes and nine recombinant human cytochromes P₄₅₀”. J. Pharmacol. Exp. Ther. 279: 1327-1334. PMID 8968357. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Quinine+3-monooxygenase