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Hinaldat 4-oksidoreduktaza
Identifikatori
EC broj	1.3.99.18
CAS broj	149885-77-8
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Hinaldat 4-oksidoreduktaza (EC 1.3.99.18, hinaldinska kiselina 4-oksidoreduktaza) je enzim sa sistematskim imenom hinolin-2-karboksilat:akceptor 4-oksidoreduktaza (hidroksilacija).^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

hinaldat + akceptor +H₂O

\rightleftharpoons

kinurenat + redukovani akceptor

Ovaj enzim iz Pseudomonas sp. takođe deluje na hinolin-8-karboksilat, dok enzim iz Serratia marcescens 2CC-1 oksiduje nikotinat. Hinaldat je supstrat oba enzima.

Reference

↑ Sauter, M., Tshisuaka, B., Fetzner, S. and Lingens, F. (1993). „Microbial metabolism of quinoline and related compounds. XX. Quinaldic acid 4-oxidoreductase from Pseudomonas sp. AK-2 compared to other procaryotic molybdenum-containing hydroxylases”. Biol. Chem. Hoppe Seyler 374: 1037-1046. PMID 8292263.
↑ Fetzner, S. and Lingens, F. (1993). „Microbial metabolism of quinoline and related compounds. XVIII. Purification and some properties of the molybdenum- and iron-containing quinaldic acid 4-oxidoreductase from Serratia marcescens 2CC-1”. Biol. Chem. Hoppe-Seyler 374: 363-376. PMID 8357532.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Quinaldate+4-oxidoreductase

[1] Sauter, M., Tshisuaka, B., Fetzner, S. and Lingens, F. (1993). „Microbial metabolism of quinoline and related compounds. XX. Quinaldic acid 4-oxidoreductase from Pseudomonas sp. AK-2 compared to other procaryotic molybdenum-containing hydroxylases”. Biol. Chem. Hoppe Seyler 374: 1037-1046. PMID 8292263.

[2] Fetzner, S. and Lingens, F. (1993). „Microbial metabolism of quinoline and related compounds. XVIII. Purification and some properties of the molybdenum- and iron-containing quinaldic acid 4-oxidoreductase from Serratia marcescens 2CC-1”. Biol. Chem. Hoppe-Seyler 374: 363-376. PMID 8357532.

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