Glutaminil-peptid ciklotransferaza

Glutaminil-peptid ciklotransferaza
Identifikatori
EC broj	2.3.2.5
CAS broj	37257-21-9
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Glutaminil-peptid ciklotransferaza (EC 2.3.2.5, glutaminil-tRNK ciklotransferaza, glutaminil ciklaza, glutaminil-transfer ribonukleatna ciklotransferaza) je enzim sa sistematskim imenom L-glutaminil-peptid gama-glutamiltransferaza (ciklizacija).^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

L-glutaminil-peptid ${\displaystyle \rightleftharpoons }$ 5-oksoprolil-peptid + NH₃

Ovaj enzim učestvuje u formiranju tirotropin oslobađajućeg hormona i drugih biološki aktivnih peptida koji sadrže N-terminalne piroglutamilne ostatke.

Reference

1. Busby, W.H., Quackenbush, G.E., Humm, J., Youngblood, W.W. and Kizer, J.S. (1987). „An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes”. J. Biol. Chem. 262: 8532-8536. PMID 3597387. 
2. Fischer, W.H. and Spiess, J. (1987). „Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides”. Proc. Natl. Acad. Sci. USA 84: 3628-3632. PMID 3473473. 
3. Messer, M. and Ottesen, M. (1965). „Isolation and properties of glutamine cyclotransferase of dried papaya latex”. C.R. Trav. Lab. Carlsberg 35: 1-24. PMID 5846578. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Glutaminyl-peptide+cyclotransferase