GTPaza proteinske sinteze

GTPaza proteinske sinteze
Identifikatori
EC broj	3.6.5.3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

GTPaza proteinske sinteze (EC 3.6.5.3, elongacioni faktor (EF), inicijacioni faktor (IF), faktor peptidnog oslobađanja ili terminacije) je enzim sa sistematskim imenom GTP fosfohidrolaza (pomoć pri iRNK translaciji).^{[1][2][3][4][5]} Ovaj enzim katalizuje sledeću hemijsku reakciju

GTP + H₂O ${\displaystyle \rightleftharpoons }$ GDP + fosfat

Ova grupa enzima pripada familiji proteina koji učestvuju u prokariotskoj, kao i u eukariotskoj, proteinskoj sintezi.

Reference

1. Kurzchalia, T.V., Bommer, U.A., Babkina, G.T. and Karpova, G.G. (1984). „GTP interacts with the γ-subunit of eukaryotic initiation factor EIF-2”. FEBS Lett. 175: 313-316. PMID 6566615. 
2. Kisselev, L.L. and Frolova, L.Yu. (1995). „Termination of translation in eukaryotes”. Biochem. Cell Biol. 73: 1079-1086. PMID 8722024. 
3. Rodnina, M.V., Savelsberg, A., Katunin, V.I. and Wintermeyer, W. (1997). „Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome”. Nature 385: 37-41. PMID 8985244. 
4. Freistroffer, D.V., Pavlov, M.Y., MacDougall, J., Buckingham, R.H. and Ehrenberg, M. (1997). „Release factor RF3 in E. coli accelerates the dissociation of release factors RF1 and RF2 from the ribosome in a GTP-dependent manner”. EMBO J. 16: 4126-4133. PMID 9233821. 
5. Krab, I.M. and Parmeggiani, A. (1998). „EF-Tu, a GTPase odyssey”. Biochim. Biophys. Acta 1443: 1-22. PMID 9838020. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Protein-synthesizing+GTPase