Fosfatidilholin desaturaza

Fosfatidilholin desaturaza
Identifikatori
EC broj	1.3.1.35
CAS broj	72536-70-0
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Fosfatidilholin desaturaza (EC 1.3.1.35, oleatna desaturaza, linoleatna sintaza, oleoil-KoA desaturaza, oleoilfosfatidilholinska desaturaza) je enzim sa sistematskim imenom 1-acil-2-oleoil-sn-glicero-3-fosfoholin:NAD⁺ Delta12-oksidoreduktaza.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

1-acil-2-oleoil-sn-glicero-3-fosfoholin + NAD⁺ ${\displaystyle \rightleftharpoons }$ 1-acil-2-linoleoil-sn-glicero-3-fosfoholin + NADH + H⁺

Ovaj enzim takođe desaturiše fosfatidilholin koji sadrži oleoil grupu na O-2 glicerolnog ostatka.

Reference

1. Pugh, E.L. and Kates, M. (1975). „Characterization of a membrane-bound phospholipid desaturase system of Candida lipolytica”. Biochim. Biophys. Acta 380: 442-453. PMID 166662. 
2. Slack, C.R., Roughan, P.G. and Browse, J. (1979). „Evidence for an oleoyl phosphatidylcholine desaturase in microsomal preparations from cotyledons of safflower (Carthamus tinctorius) seed”. Biochem. J. 179: 649-656. PMID 475773. 
3. Stymne, S. and Åppelqvist, L.-A. (1978). „The biosynthesis of linoleate from oleoyl-CoA via oleoyl-phosphatidylcholine in microsomes of developing safflower seeds”. Eur. J. Biochem. 90: 223-229. PMID 710426. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Phosphatidylcholine+desaturase