Fitepsin

Fitepsin
Identifikatori
EC broj	3.4.23.40
CAS broj	219715-98-7
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Fitepsin (EC 3.4.23.40, Phytepsin) je enzim.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Postoji preferencija za hidrofobne ostatke Phe, Val, Ile, Leu, i Ala u P1 i P1', ali se takođe razlažu -Phe-Asp- i -Asp-Asp- veze u 2S albuminu iz biljnog semena

Ovaj enzim je pristan u zrnima ječma.

Reference

1. Runeberg-Roos, P., Törmäkangas, K. and Östman, A. (1991). „Primary structure of a barley-grain aspartic proteinase. A plant aspartic proteinase resembling mammalian cathepsin D”. Eur. J. Biochem. 202: 1021-1027. PMID 1722454. 
2. Kervinen, J., Sarkkinen, P., Kalkkinen, N., Mikola, L. and Saarma, M. (1993). „Hydrolytic specificity of the barley grain aspartic proteinase”. Phytochemistry 32: 799-803. PMID 7763475. 
3. Asakura, T., Watanabe, H., Abe, K. and Arai, S. (1995). „Rice aspartic proteinase, oryzasin, expressed during seed ripening and germination, has a gene organization distinct from those of animal and microbial aspartic proteinases”. Eur. J. Biochem. 232: 77-83. PMID 7556174. 
4. Kervinen, J., Törmäkangas, K., Runeberg-Roos, P., Guruprasad, K., Blundell, T. and Teeri, T.H. (1995). „Structure and possible function of aspartic proteinases in barley and other plants”. Adv. Exp. Med. Biol. 362: 241-254. PMID 8540324. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Phytepsin