Feoforbid a oksigenaza

Feoforbid a oksigenaza
Identifikatori
EC broj	1.14.12.20
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Feoforbid a oksigenaza (EC 1.14.12.20, feid a monooksigenaza, feid a oksigenaza, PAO) je enzim sa sistematskim imenom feoforbid-a,NADPH:kiseonik oksidoreduktaza (formira biladien).^{[1][2][3][4][5][6]} Ovaj enzim katalizuje sledeću hemijsku reakciju

feoforbid a + NADPH + H⁺ + O₂ ${\displaystyle \rightleftharpoons }$ red hlorofil katabolit + NADP⁺

This enzim katalizuje ključnu reakciju u hlorofilnoj degradaciji, do koje dolazi tokom starenja lišća i zrenja voća kod viših biljki.

Reference

1. Hörtensteiner, S., Wüthrich, K.L., Matile, P., Ongania, K.H. and Kräutler, B. (1998). „The key step in chlorophyll breakdown in higher plants. Cleavage of pheophorbide a macrocycle by a monooxygenase”. J. Biol. Chem. 273: 15335-15339. PMID 9624113. 
2. Pružinská, A., Tanner, G., Anders, I., Roca, M. and Hörtensteiner, S. (2003). „Chlorophyll breakdown: pheophorbide a oxygenase is a Rieske-type iron-sulfur protein, encoded by the accelerated cell death 1 gene”. Proc. Natl. Acad. Sci. USA 100: 15259-15264. PMID 14657372. 
3. Chung, D.W., Pružinská, A., Hörtensteiner, S. and Ort, D.R. (2006). „The role of pheophorbide a oxygenase expression and activity in the canola green seed problem”. Plant Physiol. 142: 88-97. PMID 16844830. 
4. Rodoni, S., Mühlecker, W., Anderl, M., Kräutler, B., Moser, D., Thomas, H., Matile, P. and Hörtensteiner, S. (1997). „Chlorophyll breakdown in senescent chloroplasts. Cleavage of pheophorbide a in two enzymic steps”. Plant Physiol. 115: 669-676. PMID 12223835. 
5. Hörtensteiner, S. (2006). „Chlorophyll degradation during senescence”. Annu. Rev. Plant Biol. 57: 55-77. PMID 16669755. 
6. Pružinská, A., Anders, I., Aubry, S., Schenk, N., Tapernoux-Lüthi, E., Müller, T., Kräutler, B. and Hörtensteiner, S. (2007). „In vivo participation of red chlorophyll catabolite reductase in chlorophyll breakdown”. Plant Cell 19: 369-387. PMID 17237353. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Spoljašnje veze

• MeSH Pheophorbide+a+oxygenase