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Dvolančana uracil-DNK glikozilaza
Identifikatori
EC broj	3.2.2.28
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Dvolančana uracil-DNK glikozilaza (EC 3.2.2.28, Mug, Dug, dsUDG, dvolančana DNK specifična UDG, dsDNK specifična UDG, UdgB, DNK glikozilaza specifična za G:T/U neusklađenost, UDG) je enzim sa sistematskim imenom uracil-dvolančana DNK dezoksiribohidrolaza (otpuštanje uracila).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

specifična hidroliza neusklađene dvolančane DNK i polinukleotida čime se oslobađa uracil

Ovaj enzim ne deluje na DNK koja sadrži T/G neusklađenost ili jednolančanu DNK koja sadrži bilo za-mesto-specifični uracil ili 3,N4-etenocitozinski ostatak.

Reference

↑ Barrett, T.E., Scharer, O.D., Savva, R., Brown, T., Jiricny, J., Verdine, G.L. and Pearl, L.H. (1999). „Crystal structure of a thwarted mismatch glycosylase DNA repair complex”. EMBO J. 18: 6599-6609. PMID 10581234.
↑ Sung, J.S. and Mosbaugh, D.W. (2000). „Escherichia coli double-strand uracil-DNA glycosylase: involvement in uracil-mediated DNA base excision repair and stimulation of activity by endonuclease IV”. Biochemistry 39: 10224-10235. PMID 10956012.
↑ Mokkapati, S.K., Fernandez de Henestrosa, A.R. and Bhagwat, A.S. (2001). „Escherichia coli DNA glycosylase Mug: a growth-regulated enzyme required for mutation avoidance in stationary-phase cells”. Mol. Microbiol. 41: 1101-1111. PMID 11555290.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Double-stranded+uracil-DNA+glycosylase

[1] Barrett, T.E., Scharer, O.D., Savva, R., Brown, T., Jiricny, J., Verdine, G.L. and Pearl, L.H. (1999). „Crystal structure of a thwarted mismatch glycosylase DNA repair complex”. EMBO J. 18: 6599-6609. PMID 10581234.

[2] Sung, J.S. and Mosbaugh, D.W. (2000). „Escherichia coli double-strand uracil-DNA glycosylase: involvement in uracil-mediated DNA base excision repair and stimulation of activity by endonuclease IV”. Biochemistry 39: 10224-10235. PMID 10956012.

[3] Mokkapati, S.K., Fernandez de Henestrosa, A.R. and Bhagwat, A.S. (2001). „Escherichia coli DNA glycosylase Mug: a growth-regulated enzyme required for mutation avoidance in stationary-phase cells”. Mol. Microbiol. 41: 1101-1111. PMID 11555290.

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