PROFILBARU.COM

Dugolančani-3-hidroksiacil-KoA dehidrogenaza
Identifikatori
EC broj	1.1.1.211
CAS broj	84177-52-6
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Dugolančani-3-hidroksiacil-KoA dehidrogenaza (EC 1.1.1.211, beta-hidroksiacil-KoA dehidrogenaza, dugolančani 3-hidroksiacil koenzim A dehidrogenaza, LCHAD) je enzim sa sistematskim imenom dugolančani-(S)-3-hidroksiacil-KoA:NAD⁺ oksidoreduktaza.^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

(S)-3-hidroksiacil-KoA dugog lanca + NAD⁺

\rightleftharpoons

3-oksoacil-KoA dugog lanca + NADH + H⁺

Ovaj enzim je prečišćen iz mitohondrijske unutrašnje membrane. Oni ima preferenciju za dugolančane supstrate. Njegova aktivnost na C16 supstratu je 6- do 15-puta veća od nego na C4 supstratu (cf. EC 1.1.1.35, 3-hidroksiacil-KoA dehidrogenaza).

Reference

↑ El-Fakhri, M. and Middleton, B. (1982). „The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria”. Biochim. Biophys. Acta 713: 270-279. PMID 7150615.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Long-chain-3-hydroxyacyl-CoA+dehydrogenase

[1] El-Fakhri, M. and Middleton, B. (1982). „The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria”. Biochim. Biophys. Acta 713: 270-279. PMID 7150615.

[1]