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Dugolančana 3-oksoacil-KoA reduktaza
Identifikatori
EC broj	1.1.1.330
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Dugolančana 3-oksoacil-KoA reduktaza (EC 1.1.1.330, dugolančana 3-ketoacil-KoA reduktaza, dugolančana beta-ketoacil-KoA reduktaza, KCR (gen), IFA38 (gen)) je enzim sa sistematskim imenom (3R)-3-hidroksiacil-KoA:NADP⁺ oksidoreduktaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

veoma dugačak lanac (3R)-3-hidroksiacil-KoA + NADP⁺

\rightleftharpoons

veoma dugačak lanac 3-oksoacil-KoA + NADPH + H⁺

Ovaj enzim je druga komponenta elongaze, mikrozomalnog proteinskog kompleksa odgovornog za produžavanje palmitoil-KoA i stearoil-KoA (i njihovih modifikovanih formi) do dugolančanih konenzima A. On je aktivan na supstratima sa lancom dugim od C16 do C34, u zavisnosti od vrste, cf. EC 2.3.1.199, dugolančana 3-oksoacil-KoA sintaza, EC 4.2.1.134, dugolančana (3R)-3-hidroksiacil-[acil-nosilac protein] dehidrataza, i EC 1.3.1.93, dugolančana enoil-KoA reduktaza.

Reference

↑ Beaudoin, F., Gable, K., Sayanova, O., Dunn, T. and Napier, J.A. (2002). „A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal β-keto-reductase”. J. Biol. Chem. 277: 11481-11488. PMID 11792704.
↑ Han, G., Gable, K., Kohlwein, S.D., Beaudoin, F., Napier, J.A. and Dunn, T.M. (2002). „The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase”. J. Biol. Chem. 277: 35440-35449. PMID 12087109.
↑ Beaudoin, F., Wu, X., Li, F., Haslam, R.P., Markham, J.E., Zheng, H., Napier, J.A. and Kunst, L. (2009). „Functional characterization of the Arabidopsis β-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase”. Plant Physiol. 150: 1174-1191. PMID 19439572.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Very-long-chain+3-oxoacyl-CoA+reductase

[1] Beaudoin, F., Gable, K., Sayanova, O., Dunn, T. and Napier, J.A. (2002). „A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal β-keto-reductase”. J. Biol. Chem. 277: 11481-11488. PMID 11792704.

[2] Han, G., Gable, K., Kohlwein, S.D., Beaudoin, F., Napier, J.A. and Dunn, T.M. (2002). „The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase”. J. Biol. Chem. 277: 35440-35449. PMID 12087109.

[3] Beaudoin, F., Wu, X., Li, F., Haslam, R.P., Markham, J.E., Zheng, H., Napier, J.A. and Kunst, L. (2009). „Functional characterization of the Arabidopsis β-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase”. Plant Physiol. 150: 1174-1191. PMID 19439572.

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