Dolihil-fosfat a-N-acetilglukozaminiltransferaza

Dolihil-fosfat a-N-acetilglukozaminiltransferaza
Identifikatori
EC broj	2.4.1.153
CAS broj	63363-73-5
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Dolihil-fosfat a-N-acetilglukozaminiltransferaza (EC 2.4.1.153, uridin difosfoacetilglukozamin-dolihol fosfatna acetilglukozaminiltransferaza, dolihil fosfatna acetilglukozaminiltransferaza, dolihil fosfatna N-acetilglukozaminiltransferaza, UDP-N-acetilglukozamin-dolihol fosfatna N-acetilglukozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:dolihil-fosfat alfa-N-acetil-D-glukozaminiltransferaza.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-N-acetil-D-glukozamin + dolihil fosfat ${\displaystyle \rightleftharpoons }$ UDP + dolihil N-acetil-alfa-D-glukozaminil fosfat

Reference

1. Leloir, L.F., Staneloni, R.J., Carminatti, H. and Behrens, N.H. (1973). „The biosynthesis of a N,N'-diacetylchitobiose containing lipid by liver microsomes. A probable dolichol pyrophosphate derivative”. Biochem. Biophys. Res. Commun. 52: 1285-1292. PMID 4717748. 
2. Molnar, J., Chao, H. and Ikehara, Y. (1971). „Phosphoryl-N-acetylglucosamine transfer to a lipid acceptor of liver microsomal preparations”. Biochim. Biophys. Acta 239: 401-410. PMID 5113503. 
3. Tetas, M., Chao, H. and Molnar, J. (1970). „Incorporation of carbohydrates into endogenous acceptors of liver microsomal fractions”. Arch. Biochem. Biophys. 138: 135-146. PMID 4315690. 
4. Warren, C.D. and Jeanloz, R.W. (1974). „Chemical synthesis of P1-2-acetamido-2-deoxy-α-D-glucopyranosyl P2-dolichyl pyrophosphate”. Carbohydr. Res. 37: 252-260. PMID 4371972. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Dolichyl-phosphate+alpha-N-acetylglucosaminyltransferase