Dipeptidilna peptidaza I

Dipeptidilna peptidaza I
Heterododekamer katepsina C (čovjek)
Identifikatori
EC broj	3.4.14.1
CAS broj	9032-68-2
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Dipeptidilna peptidaza I (EC 3.4.14.1, katepsin C, dipeptidilna aminopeptidaza I, dipeptidilna transferaza, katepsin C, dipeptidilna transferaza, dipeptidna arilamidaza I, DAP I) je enzim.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Odvajanje N-terminalnog dipeptida, Xaa-Yaa-Zaa-, izuzev kad je Xaa: Arg ili Lys, ili je Yaa: Zaa ili Pro

Ovaj enzim je zavistan od jona Cl^-.

Reference

1. Planta, R.J., Gorter, J. and Gruber, M. (1964). „The catalytic properties of cathepsin C”. Biochim. Biophys. Acta 89: 511-519. PMID 14209333. 
2. Metrione, R.M., Neves, A.G. and Fruton, J.S. (1966). „Purification and properties of dipeptidyl transferase (cathepsin C)”. Biochemistry 5: 1597-1604. PMID 5961281. 
3. McDonald, J.K., Zeitman, B.B., Reilly, T.J. and Ellis, S. (1969). „New observations on the substrate specificity of cathepsin C (dipeptidyl aminopeptidase I) including the degradation of β-corticotropin and other peptide hormones”. J. Biol. Chem. 244: 2693-2709. PMID 4306035. 
4. McDonald, J.K. and Schwabe, C. (1977). „Intracellular exopeptidases”. u: Barrett, A.J.. Proteinases in Mammalian Cells and Tissues. Amsterdam: North-Holland Publishing Co.. str. 311-391. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

• McDonald, J.K. and Schwabe, C. (1977). „Intracellular exopeptidases”. u: Barrett, A.J.. Proteinases in Mammalian Cells and Tissues. Amsterdam: North-Holland Publishing Co.. str. 311-391. 

Vanjske veze

• MeSH Dipeptidyl-peptidase+I