Dihidrofolna kiselina

Dihidrofolna kiselina
IUPAC ime

 DaY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

benzoil)-L-glutaminska kiselina

| OtherNames = H2folat, DH | Section1 = ! align="center" cellspacing="3" style="border: 1px solid #C0C090; background-color: #F8EABA; margin-bottom: 3px;" colspan="2" | Identifikacija |-


| CAS registarski broj | 4033-27-6 |-

| PubChem[1][2] | 98792 |-

| ChemSpider[3] | 89228 DaY |-





| MeSH | dihydrofolate |- | ChEBI | 15633 |-

| ChEMBL[4] | {{#if:46294|CHEMBL46294 DaY |-





| Jmol-3D slike | {{#if:O=C(O)[C@@H](NC(=O)c1ccc(cc1)NCC/2=N/C=3C(=O)\N=C(/NC=3NC\2)N)CCC(=O)O|Slika 1 |-

| align="center" colspan="2" |

|-

| align="center" colspan="2" |

|- | Section2 = ! align="center" cellspacing="3" style="border: 1px solid #C0C090; background-color: #F8EABA; margin-bottom: 3px;" colspan="2" | Svojstva |- | Molekulska formula | C19H21N7O6 |- | Molarna masa | 443,414 g/mol |- | Section3 = }}

Dihidrofolna kiselina (dihidrofolat, vitamin B9) je derivat folne kiseline koji se konvertuje u tetrahidrofolnu kiselinu posredstvom dihidrofolatne reduktaze. Tetrahidrofolat je neophodan za formiranje purina i pirimidina, koji su gradivni blokovi DNK i RNK. Dihidrofolat reduktaza je meta lekova koji sprečavaju sintezu nukleinskih kiselina.[5]

Reference

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. E. L R. Stokstad and T. H. Jukes (1987). „Sulfonamides and Folie Acid Antagonists: A Historical Review”. J. Nutr. 117: 1335-1341. 

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